say all good things are made lawful for
- Slides: 48
• ……say: ( all ) good things are made lawful for you, so eat of that which they catch for you and mention Allah’s name upon it…… 4 -The. Table Spread Digestion & Absorption Dr Jariya Wajahat
Proteins Digestion and absorption Digestion & Absorption Dr Jariya Wajahat
PROTEOLYTIC ENZYMES Digestion & Absorption Dr Jariya Wajahat
Proteolytic enzymes Zymogens Digestion & Absorption Active enzymes Dr Jariya Wajahat
Classification of Proteases Exopeptidases Polypeptidases Aminopeptidases Carboxypeptidases Tripeptidases Dipeptidases Endopeptidases Pepsin Trypsin Chymotrypsin Elastase Digestion & Absorption Dr Jariya Wajahat
Stomach DIGESTION OF PROTEINS Digestion & Absorption Dr Jariya Wajahat
Stomach • Parietal cells – HCl • Chief cells – Pepsin (endopeptidase) Digestion & Absorption Dr Jariya Wajahat
Acidic and aromatic amino acids Pepsinogen Digestion & Absorption H+ Dr Jariya Wajahat Pepsin
Exocrine pancreas DIGESTION OF PROTEINS Digestion & Absorption Dr Jariya Wajahat
Exocrine pancreas • Bicarbonate • Pancreatic proteases – Zymogens Digestion & Absorption Dr Jariya Wajahat
Activation • Trypsinogen Enterokinase → Trypsin • Chymotrypsinogen→ Chymotrypsin • Proelastase →Elastase • Procarboxypeptidase → Carboxypeptidase Digestion & Absorption Dr Jariya Wajahat
Arginine and lysine • Trypsin Digestion & Absorption Dr Jariya Wajahat
Acidic and hydrophobic amino acids • Chymotrypsin Digestion & Absorption Dr Jariya Wajahat
Alanine, glycine and serine • Elastase Digestion & Absorption Dr Jariya Wajahat
Hydrophobic and basic amino acids • Carboxypeptidase – Carboxypeptidase A – Carboxypeptidase B Digestion & Absorption Dr Jariya Wajahat
Intestine DIGESTION OF PROTEINS Digestion & Absorption Dr Jariya Wajahat
Intestinal enzymes • Exopeptidases – Brush border – Within the cell • Enterokinase Digestion & Absorption Dr Jariya Wajahat
Intestinal enzymes • Aminopeptidase Digestion & Absorption Dr Jariya Wajahat
Which of the following enzymes is activated through an autocatalytic process? • Enteropeptidase • Proelastase • Pepsinogen Digestion & Absorption Dr Jariya Wajahat
Intestinal brush border ABSORPTION OF AMINO ACIDS Digestion & Absorption Dr Jariya Wajahat
Transport systems • Na Dependent – Neutral – Proline hydroxyproline – Acidic – Basic and cystine • 2. Na Independent – Facilitated transport Digestion & Absorption Dr Jariya Wajahat
2 K+ 3 Na+ Digestion & Absorption Dr Jariya Wajahat
Na+ Digestion & Absorption Dr Jariya Wajahat
Na+ Digestion & Absorption Dr Jariya Wajahat
Na+ Digestion & Absorption Dr Jariya Wajahat
Na+ Digestion & Absorption Dr Jariya Wajahat
Na+ Digestion & Absorption Dr Jariya Wajahat
DISORDERS OF PROTEIN DIGESTION Digestion & Absorption Dr Jariya Wajahat
Disorders of protein digestion • • Cystic fibrosis Cystinuria Hartnup disease Kwashiorkor Digestion & Absorption Dr Jariya Wajahat
Cystic fibrosis Digestion & Absorption Dr Jariya Wajahat
Cystic fibrosis • Defect in function of chloride channels in pancreatic secretory ducts • Inspissation of pancreatic exocrine secretions • Eventual obstruction of ducts Digestion & Absorption Dr Jariya Wajahat
Cystic fibrosis • Clinical features – Recurrent infections – Poor growth – Foul smelling bulky stools • Treatment – Commercial enzyme preparations Digestion & Absorption Dr Jariya Wajahat
Hartnup disease • Defect – Autosomal recessive disorder – Transport of neutral amino acids across both intestinal and renal epithelial cells Digestion & Absorption Dr Jariya Wajahat
Hartnup disease Essential • • • Isoleucine Leucine Phenylalanine Threonine Tryptophan Valine Digestion & Absorption Non essential • Alanine • Serine • Tyrosine Dr Jariya Wajahat
Hartnup disease • Clinical features – Asymptomatic – Pallegra like symptoms – Neuropsychiatric • Treatment – Niacin Digestion & Absorption Dr Jariya Wajahat
Cystinuria • Defect in absorption of – – Cystine Ornithine Arginine Lysine • Clinical features – Appearance of above mentioned amino acids in urine – Cystine stones • Treatment – Oral hydration Digestion & Absorption Dr Jariya Wajahat
Kwashiorkor • Cause – Deficiency of protein in diet adequate in calories • Clinical features – Muscle wasting – Edema Digestion & Absorption Dr Jariya Wajahat
In hartnup disease there is defect in absorption of aa? • Neutral • Acidic • Basic Digestion & Absorption Dr Jariya Wajahat
THE END Digestion & Absorption Dr Jariya Wajahat
Digestion & Absorption Dr Jariya Wajahat
Digestion & Absorption Dr Jariya Wajahat
Hartnup Digestion & Absorption Dr Jariya Wajahat
Hartnup Digestion & Absorption Dr Jariya Wajahat
Hartnup Digestion & Absorption Dr Jariya Wajahat
WELL DONE! Digestion & Absorption ENZYMES Dr Jariya Wajahat
YOU NEED BETTER CONCEPTS! Digestion & Absorption Dr Jariya Wajahat ENZYMES
YOU MISSED IT! ENZYMES Digestion & Absorption Dr Jariya Wajahat
THE END Digestion & Absorption Dr Jariya Wajahat