Saratin mechanism of action v WF 12242021 Platelet

Saratin - mechanism of action v. WF 12/24/2021 Platelet 12/24/2021 Biomedical R&D Folie (slide) 1

Saratin - mechanism of action v. WF 12/24/2021 Platelet 12/24/2021 Biomedical R&D Folie (slide) 2

Saratin - mechanism of action 12/24/2021 v. WF 12/24/2021 Platelet 12/24/2021 Biomedical R&D Folie (slide) 3

Saratin - mechanism of action 12/24/2021 v. WF 12/24/2021 Platelet 12/24/2021 Biomedical R&D Folie (slide) 4

Saratin - mechanism of action 12/24/2021 v. WF 12/24/2021 Platelet 12/24/2021 Biomedical R&D Folie (slide) 5

Saratin - mechanism of action 12/24/2021 v. WF 12/24/202 Platelet 12/24/2021 Biomedical R&D Folie (slide) 6

Saratin - mechanism of action 12/24/2021 v. WF Platelet 12/24/2021 Biomedical R&D Folie (slide) 7

Saratin - mechanism of action 12/24/2021 Platelet 12/24/2021 Biomedical R&D Folie (slide) 8

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 9

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 10

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 11

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 12

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 13

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 14

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 15

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 16

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 17

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 18

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 19

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 20

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 21

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 22

Saratin - mechanism of action 12/24/2021 Vessel wall injury exposes collagen to elements of flowing blood. 12/24/2021 Biomedical R&D Folie (slide) 23

Saratin - mechanism of action 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 24 12

Saratin - mechanism of action 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 25

Saratin - mechanism of action 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 26

Saratin - mechanism of action 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 27

Saratin - mechanism of action 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 28

Saratin - mechanism of action 12/24/2021 v. WF A 3 domain binds to collagen. 12/24/2021 Biomedical R&D Folie (slide) 29

Saratin - mechanism of action 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 30

Saratin - mechanism of action 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 31

Saratin - mechanism of action 12/24/2021 12/24/202 v. WF A 1 domain targets GP Ib/IX/V receptor of circulating platelets, “tethering” them to the vessel wall. 12/24/2021 Biomedical R&D Folie (slide) 32

Saratin - mechanism of action 1 1 02 02 2 2 / / /24 12 12 12/24/2021 1 02 2 / /24 12 Biomedical R&D Folie (slide) 33

Saratin - mechanism of action 1 1 02 02 2 2 / / /24 12 12 12/24/2021 1 02 2 / /24 12 Biomedical R&D Folie (slide) 34

Saratin - mechanism of action 1 02 2 / /24 12 Direct collagen-platelet interactions (GP Ia/IIa, GP VI etc. ) anchor and then lead to activation of the tethered platelet. 12/24/2021 Biomedical R&D Folie (slide) 35

Saratin - mechanism of action 1 02 2 / /24 12 12/24/2021 Biomedical R&D Folie (slide) 36

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 37

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 38

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 39

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 40

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 41

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 42

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 43

Saratin - mechanism of action 1 02 2 / /24 12/24/2021 12/24/2021 Occlusive thrombus! Biomedical R&D Folie (slide) 44

Saratin - mechanism of action How does saratin interfere with arterial thrombosis? 12/24/2021 Biomedical R&D Folie (slide) 45

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 46

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 47

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 48

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 49

Saratin - mechanism of action 12/24/2021 Biomedical R&D Folie (slide) 50

Saratin - mechanism of action S 12/24/2021 Biomedical R&D Folie (slide) 51

Saratin - mechanism of action S 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 52 12

Saratin - mechanism of action S 12/24/2021 S S 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 53

Saratin - mechanism of action S 12/24/2021 S S S 12/24/2021 Saratin binds to collagen, preventing interaction with v. WF and hence platelets. 12/24/2021 Biomedical R&D Folie (slide) 54

Saratin - mechanism of action S 12/24/2021 S S S 12/24/2021 Biomedical R&D Folie (slide) 55

Saratin - mechanism of action S S 12/24/2021 Biomedical R&D Folie (slide) 56

Saratin - mechanism of action S 12/24/2021 S S S 12/24/2021 Biomedical R&D Folie (slide) 57

Saratin - mechanism of action S 12/24/2021 S S S 12/24/2021 Biomedical R&D Folie (slide) 58

Saratin - mechanism of action S S S 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 59

Saratin - mechanism of action S S S 12/24/2021 12/24/2021 Biomedical R&D Folie (slide) 60

Saratin - mechanism of action 1 1 02 02 2 2 / / S/24 12 S 12 12/24/2021 S 1 S 24/202 / 12 Biomedical R&D Folie (slide) 61

Saratin - mechanism of action 1 1 02 02 2 2 / / S/24 12 S 12 12/24/2021 S 1 S 24/202 / 12 Biomedical R&D Folie (slide) 62

Saratin - mechanism of action 1 02 2 / /24 S 12 S S 1 S 24/202 / 12 Saratin acts as a molecular plaster, neutralising platelets BEFORE they adhere and become activated. 12/24/2021 Biomedical R&D Folie (slide) 63