Sarah Fowler Res Professor of Biostat Epi Director
Sarah Fowler Res. Professor of Biostat. & Epi. Director, Biostatistics Center Ph. D in Mathematical Statistics Specialties: statistical design, conduct, and analysis of multicenter clinical trials Funding: NIH/NIDDK, NHLBI fowler@biostat. bsc. gwu. edu 301 -881 -9260 1
GWU Biostatistics Center n Established 1972, Statistics n Faculty affiliations in SPHHS/DEB n Administratively in office of EVPAA n 12 faculty, 150 + employees n n Research awards to BSC investigators: $63 million/ year 16 grants and contracts, duration 3 years – 40 years
Diabetes Prevention Program n Interventions to prevent/delay onset of Type II DM in 3234 subjects at high risk n Groups compared: lifestyle (ILS), metformin, and placebo n Results: The DPP Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346: 393403, 2002. n Cohort being followed for 10 years, ending in 2012 3
Results of the DPP 158, 000 screened, 3819 enrolled Placebo Metformin Life-style Incidence of diabetes 11. 0% 7. 8% (percent per year) Reduction in incidence compared with placebo ---- 31% Number needed to treat to prevent 1 case in 3 yrs ---- 13. 9 n 4. 8% 58% 6. 9 Results are similar across ethnic groups 4
Pulmonary Embolism Diagnosis n PIOPED II: diagnostic accuracy of multi-detector spiral CT angiography/venography n 773 patients evaluated by CT and reference n Stein PD, et al. Multidetector Spiral CT For Acute Pulmonary Embolism: Results Of The PIOPED II Trial. N Engl J Med 2006; 354: 2317 -27 Results Sensitivity Specificity CTA alone: 83%(76 -92) 96%(93 -97) CTA/CTV: 90%(84 -93) 95%(92 -96) CTA/CTV replaces more invasive tests n PIOPED III: evaluating MR angiography/ venography (can be used in pregnant women and patients with renal disease) 5
- Slides: 5