Samenwerkingsverband tussen IWT Vlaanderen en het departement Economie

Samenwerkingsverband tussen IWT Vlaanderen en het departement Economie, Wetenschap en Innovatie van de Vlaamse overheid FP 7 research funding opportunities in the field of neuroscience Alain Deleener - IWT National Contact Point FP 7 Health for Flanders (Belgium)

EU support for Research and Innovation FP 7 funding opportunities for neuroscience complementary programmes, from research to market. • The € 55 billion Seventh Framework Programme supports basic and applied research activities, still far from the market, leverages money and concentrate resources on strategic research areas, always on the basis of technological and scientific excellence. • The Competitiveness and Innovation Framework Programme does not finance research, but supports innovation activities, provides better access to finance and delivers business support services in the regions. • Structural funds have just as much funding as FP 7, however FP 7 concentrates on excellence for competitiveness, while the Structural Funds' main objective is cohesion. However, there are synergies between these programmes. 2

FP 7 Structure and Budget FP 7 funding opportunities for neuroscience EC Framework Programme is delineated into four Specific Programmes; total budget of € 50. 52 billion Euratom Cooperation JRC (EC) 4, 061 1, 751 Capacities 4, 097 Ideas (European Research Council) People 4, 75 Cooperation 32, 413* People 7, 51 Ideas Capacities *of which Health € 6. 1 billion Total FP 7 budget, including EURATOM: € 54, 582 billion

Collaborative research in FP 7: The Cooperation programme FP 7 funding opportunities for neuroscience Thematic Priorities 1. 2. 3. 4. 5. 6. 7. 8. 9. Health Food, agriculture, fisheries and biotechnology Information and communication technologies Nanosciences, nanotechnologies, materials and new production technologies Energy Environment (including climate change) Transport (including aeronautics) Socio-economic sciences and the humanities Security & 10. Space Total for collaborative research 6. 1 1. 9 9. 1 3. 5 2. 3 1. 9 4. 2 0. 6 2. 8 € 32. 4 billion 4

Cooperation – ‘Tools’ FP 7 funding opportunities for neuroscience • Under each theme there will be sufficient flexibility to address both Emerging needs and Unforeseen policy needs • Dissemination of knowledge and transfer of results will be supported in all thematic areas • Support will be implemented across all themes through: Collaborative research (Collaborative projects; Networks of Excellence; Coordination/support actions) Joint Technology Initiatives Coordination of non-Community research programmes (ERA-NET; ERA-NET+; Article 169) International Cooperation

Collaborative research in FP 7: The Cooperation programme FP 7 funding opportunities for neuroscience Thematic Priorities 1. 2. 3. 4. 5. 6. 7. 8. 9. Health Food, agriculture, fisheries and biotechnology Information and communication technologies Nanosciences, nanotechnologies, materials and new production technologies Energy Environment (including climate change) Transport (including aeronautics) Socio-economic sciences and the humanities Security & 10. Space collaborative research € 32. 4 billion 6. 1 1. 9 9. 1 3. 5 2. 3 1. 9 4. 2 0. 6 2. 8 Total for 6

Scope of research in the Health Theme FP 7 funding opportunities for neuroscience • In the Health theme, the Framework programme can support both basic and applied research • This includes discovery activities, translational research and clinical trials (normally only phase I and II).

Health research in FP 7 funding opportunities for neuroscience Pillar 1: Pillar 2: Pillar 3: Biotechnology, generic tools & technologies for health Translating research for human health Optimising the delivery of health care cross-cutting issues: child health, the health of ageing population gender-related health issues Public Health Translational Biotech Health Budget: € 6. 1 billion over 7 years (2007 -2013)

Health research in FP 7 1: Biotechnology, generic tools and technologies FP 7 funding opportunities for neuroscience § High-throughput research technologies for: sequencing (genotyping, phenotyping, gene expression) structural / functional genomics, bioinformatics, systems biology § Detection, diagnosis and monitoring tools and technologies for: visualisation, imaging, detection and analysis § Predicting suitability, safety and efficacy of therapies pharmacogenomics, biomarkers, targeting and delivery approaches (incl. alternatives to animal testing), and in vivo methods and models § Innovative therapeutic approaches & intervention Public Health Translational Biotech Health gene and cell therapy, regenerative medicine, transplantation, immunotherapy and vaccines

Health research in FP 7 2: Translating research for human health (1) FP 7 funding opportunities for neuroscience § Integrating biological data and processes large-scale data gathering: generate data to elucidate the function of genes and gene products and their interaction in complex networks systems biology: to develop and apply systems approaches to understand model biological processes § Research on the brain and related diseases to better understand the integrated structure and dynamics of the brain, and to study brain diseases, incl age-related ones: dementia, Parkinson § Human development and ageing Public Health Translational Biotech Health to better understand the process of life-long development and healthy ageing

Health research in FP 7 2: Translating research for human health (2) FP 7 funding opportunities for neuroscience § Translational research in infectious diseases: § drug resistance § HIV / AIDS, malaria, tuberculosis § hepatitis § new and re-emerging epidemics § Translational research in major diseases: (~ 20 -25% of request) Public Health Translational Biotech Health § cancer § cardiovascular disease § diabetes / obesity § rare diseases § other chronic diseases e. g. rheumatic, respiratory, musculo-skeletal diseases & arthritis)

Health research in FP 7 3: Optimising the delivery of health care FP 7 funding opportunities for neuroscience § Translating clinical outcome into clinical practice patient safety, best clinical practice, decision making in clinical settings in primary and specialised care, foster application of evidence-based medicine § Quality, efficiency and solidarity of health systems organizational, financial and regulatory aspects of health systems Public Health Translational Biotech Health § Enhanced disease prevention and better use of medicines provide scientific evidence for best public health measures

Work programme 2010 preparation (4 th call) Roadmap FP 7 funding opportunities for neuroscience Strategy Paper >> DG and Commissioner (Nov. -Dec. ‘ 08) Reflection paper >> 1 st PC meeting (12 January ‘ 09) Draft WP >> 2 nd PC meeting (5 March ‘ 09 ? ) Draft WP >> Inter-service Consultation (May) Draft WP >> PC formal opinion (June) Work Programme adoption (July) & publication in July or September

Research priorities for 4 th call FP 7 funding opportunities for neuroscience Important features: • focus on 4 key research challenges • some areas closed • will probably be split into 2 or 3 calls • 2 -stage submission for some areas/topics focus on 4 Key Research Challenges • Providing tools for translational research • Structuring translational research in the field of cancer • Structuring translational research in the field of neurodegenerative diseases. • Better health for Africa

Funding schemes in the Health theme (4 th call) FP 7 funding opportunities for neuroscience Funding schemes upper limits Large-scale integrating project (CP-IP) € 12 m Network of excellence (No. E) to be specified Small- or medium-scale focussed research project (CP- € 3 m or € 6 m FP) Coordination action (CA) € 2 m Support action (SA) € 0. 5 m

FP 7 – Health 4 th call topics (1/5) FP 7 funding opportunities for neuroscience Biotech, tools & technologies 1. 1 – High-throughput research 1. Harmonisation of phenotyping and biosampling for clinical research. Funding scheme: Large scale integrating project. ! Topics communicated with reservation !

FP 7 – Health 4 th call topics (2/5) FP 7 funding opportunities for neuroscience Biotech, tools & technologies 1. 2 – Detection, diagnosis and monitoring 1. Tools for the identification and the detection of biomarkers in clinical samples and patients. • Multimodality biomarker analysis • Tools for detection, isolation and functional characterization of complexes of interacting molecules for diagnostic purposes • Development of new quantitative imaging biomarker(s) for monitoring therapeutic effects and safety in chronic diseases • High throughput molecular diagnostic imaging • Development and implementation of quantum imaging of X-rays/Y-rays for diagnosis Funding scheme: Small or medium-scale focused research projects. (2 -stage) ! Topics communicated with reservation !

FP 7 – Health 4 th call topics (3/5) FP 7 funding opportunities for neuroscience Translating research for health 2. 1 – Integrating biological data and processes: 2. 1. 2 – Systems biology 1. Tackling Human Diseases through Systems Biology Approaches. Funding scheme: Large-scale integrating projects. (2 -stage) 2. Creating European multidisciplinary networks to address systems biology of basic biological processes relevant to health. Funding scheme: Network of Excellence. (2 -stage) 3. Coordination and support actions in large-scale data gathering and systems biology. Funding scheme: Coordinating Action. 4. Developing new and improving existing mathematical algorithms for systems biology. Funding scheme: SICA Small or medium-scaled focused research project ! Topics communicated with reservation !

FP 7 – Health 4 th call topics (4/5) FP 7 funding opportunities for neuroscience Translating research for health 2. 2. 1 – Research on the Brain and related diseases: 1. Validation of strategies for treating addiction. Funding scheme: Large scale integrating project. 2. Actions to support dissemination of scientific knowledge in neuroscience. Funding scheme: Supporting Action. Also considering possible initiatives linked to Joint Programming for research on neurodegenerative diseases. ! Topics communicated with reservation !

FP 7 – Health 4 th call topics (5/5) FP 7 funding opportunities for neuroscience Translating research for health 2. 2. 2 – Human development and ageing: 1. Role of early-life developmental processes in longevity determination. Funding scheme: Large-scale integrating project. (2 -stage) 2. Homeostasis in human development and its effects on lifespan. Funding scheme: Small or medium-scale focused research project. (2 -stage) ! Topics communicated with reservation !

Collaborative research in FP 7: The Cooperation programme FP 7 funding opportunities for neuroscience Thematic Priorities 1. 2. 3. 4. 5. 6. 7. 8. 9. Health Food, agriculture, fisheries and biotechnology Information and communication technologies Nanosciences, nanotechnologies, materials and new production technologies Energy Environment (including climate change) Transport (including aeronautics) Socio-economic sciences and the humanities Security & 10. Space Total for collaborative research 6. 1 1. 9 9. 1 3. 5 2. 3 1. 9 4. 2 0. 6 2. 8 € 32. 4 billion 21

FP 7 – ICT call topics (1/4) FP 7 funding opportunities for neuroscience Challenge 2: Cognitive Systems and Robotics Ø Objective ICT-2009. 2. 1: Cognitive Systems and Robotics “Pertinent research may be informed by neuro- and behavioural sciences and determine the requirements basic technologies have to meet in order to enable creating the targeted systems. ”

FP 7 – ICT call topics (2/4) FP 7 funding opportunities for neuroscience Challenge 4: Towards sustainable and personalised healthcare Ø Objective ICT-2009. 5. 1: Personal Health Systems § Target outcome b): Mental health ICT based solutions for persons suffering from stress, depression or bipolar disorders (other mental disorders are not in scope). Interdisciplinary research will address the parallel development of technological solutions, as well as new management or treatment models based on closed-loop approaches. Emphasis will be on the use of multiparametric monitoring systems, which monitor various metrics related to behaviour and to bodily and brain functions (e. g. activity, sleep, physiological and biochemical parameters). Ø Objective ICT-2009. 5. 3: Virtual Physiological Human “Coordination/Support action to develop an observatory on the achievements and evolution of the broader Biomedical Informatics field which builds on synergies between bioinformatics, medical informatics, and neuroinformatics. The action should incorporate intensive dissemination and training components and facilitate communication between projects.

FP 7 – ICT call topics (3/4) FP 7 funding opportunities for neuroscience Challenge 7: ICT for Independent Living, Inclusion and Governance Ø Objective ICT-2009. 7. 2: Accessible and Assistive ICT “ICT restoring and augmenting human capabilities compensating for people with reduced motor functions or disabilities: Radically new ICT-enabled approaches to restore and augment the ability of people in their daily life with a focus on reduced motor functions. Research should aim for breakthroughs in the way humans interact with computers and how they may overcome their disability and augment their capabilities. The research should build on progress in non-invasive sensor and actuator concepts for brain/neuronal-computer interaction (BNCI), smart bio-sensors, selflearning/adaptive systems and advanced signal processing. ”

FP 7 – ICT call topics (4/4) FP 7 funding opportunities for neuroscience 4. 8 Future and Emerging Technologies (Open call – cut off dates) Radical breakthroughs in ICT increasingly rely on fresh synergies, crosspollination and convergence with different scientific disciplines (for instance, biology, chemistry, nanoscience, neuro- and cognitive science, ethology, social science, economics) and with the arts and humanities. Ø Objective ICT-2009. 8. 4: FET proactive 4: Human-Computer Confluence. Ø Objective ICT-2009. 8. 8: FET proactive 8: Brain Inspired ICT § Target outcome a) Development of multi-scale models of information processing and communication in the brain and/or PNS. b) Synthetic Hardware Implementations of Neural Circuits

FP 7 – ICT future calls FP 7 funding opportunities for neuroscience Next calls in 2009 • in June (deadline October/November) • in November (deadline beginning 2010) • every 2 calls all topics will be open FET : open call with cut off dates

FP 7: from call to project FP 7 funding opportunities for neuroscience Calls proposals e-proposal EPSS evaluation ranking EC decision negotiation GPF-file GA Project 27

Evaluation & submission procedures FP 7 funding opportunities for neuroscience • Evaluations may follow a single or a two-step evaluation procedure or two-stage submission procedure • The applicable procedure will be set out in the call • Two-step evaluation procedure, only proposals that pass the 1 st step, based on the evaluation against a limited set of criteria, will go forward for further evaluation • Two-stage submission procedure, only applicants whose proposals pass the evaluation for the 1 st stage will be requested to submit a complete proposal in the 2 nd stage 28 Brussels 30 Jan 2007

Who can participate? FP 7 funding opportunities for neuroscience • Any undertaking, university or research centre or other legal entity, whether established in a: o Member State (MS) o Associated country (Ac) , or o third country • Joint Research Centre (JRC) - is deemed to be established in another MS or Ac • International organisations and participants from third countries can participate only if in addition to the minima 29 Brussels 30 Jan 2007

Conditions for participation FP 7 funding opportunities for neuroscience • Minimum condition, general rule, at least 3 independent participants from 3 different MS or Ac • Additional conditions can be established by the SP or WP (number or type of participant, place of establishment) • Specific conditions may also apply for: o Frontier research actions, at least 1 legal entity established in a MS or Ac o Collaborative projects addressing the participation of International Cooperation Partner Countries (ICPC) minimum is 4 participants, 2 of which from MS or Ac and another 2 from ICPC countries unless otherwise foreseen in the WP 30 Brussels 30 Jan 2007

Criteria for evaluation FP 7 funding opportunities for neuroscience • The Commission will evaluate the proposals submitted according to the following main criteria: o Scientific and/or technological excellence o relevance to the topic of the call o quality and efficiency of the implementation and management o potential impact of project results • Additional requirements on the application of these criteria may be added in the work programmes • For research actions under the IDEAS Programme the sole criterion of excellence will apply 31 Brussels 30 Jan 2007

Eligibility for funding FP 7 funding opportunities for neuroscience • Legal entities from MS and Ac or created under Community law and the JRC • International European interest organisations • Legal entities established in international cooperation partner countries (ICPC), and • International organisations and legal entities from third countries other than ICPC only if: o provided for in SP or WP; or o their contribution is essential for carrying out action; or o provision for funding is provided for in a bilateral agreement between Community and the third country 32 Brussels 30 Jan 2007

Upper funding limits FP 7 funding opportunities for neuroscience Reimbursement will be according to the type of action and/or activity • Research and technological development activities: up to 50% of eligible costs, or up to 75% for: • Non profit public bodies • secondary and higher education establishments • research organisations • SMEs • Security related research, for highly reliable capabilities with impact on security of European citizens and targeted to a limited number of public users • Demonstration activities: up to 50% • Other activities including management: up to 100% • Actions that will be reimbursed up to 100%: • Frontier research • Coordination and support • Training and career development of researchers 33 Brussels 30 Jan 2007

Reimbursement of eligible costs FP 7 funding opportunities for neuroscience • Most funding schemes use reimbursement of eligible costs o Eligible § actual (average personnel costs may be used if do not differ significantly from actual) § incurred during duration of project § in accordance with the beneficiary usual accounting and management principles § recorded in the accounts of beneficiary § used for the sole purpose of achieving the objectives of the project o Non-eligible (identifiable indirect taxes including VAT…) 34 Brussels 30 Jan 2007

Indirect Cost FP 7 funding opportunities for neuroscience • Participants may charge eligible direct and indirect costs • Reimbursement of indirect costs : o For all: § either actual overhead, or simplified method, or § flat rate of 20% of direct costs o For Non profit Public Bodies, Secondary and Higher Education establishments, Research Organisations, and SMEs unable to identify real indirect costs, may apply for a flat rate of 60% for funding schemes with Research, Technological Development & Demonstration o For Coordination and Support Actions limit of § 7% of direct costs 35 Brussels 30 Jan 2007

How to use FP 7 Do and don’t… FP 7 funding opportunities for neuroscience • Match your objectives with the Programme funding opportunities. Have a clear vision of what you want to get. • Do it only if it corresponds to your strategic goals. • Use the various supporting options…. 36

Consortium size and composition FP 7 funding opportunities for neuroscience There is no ideal size: Ø whether it is for small, medium or large proposals, the consortium must be composed of the right set of competences and resources Ø large Integrating projects do not necessarily require large consortia Ø there are not “political” / “geographical” requirements, although there should not be obvious imbalances eg: 5 out of 7 partners from same country

Key factors for success in applying for FP 7 funding opportunities for neuroscience Competition is tough: only the best projects get funded Ø The proposal must be in scope with the topic and the work programme (not wishful thinking) Ø The consortium of partners must be excellent and appropriate for the task (select the right partners) Ø The proposal must address all 3 criteria Ø Convince the evaluators (don’t rely on reputation) Ø and, of course, respect the basic rules (deadlines, n° participants, ceilings, length, ethics, …)