Safety Methyl Iodide 8 November 2018 Eleen Laul

Safety: Methyl Iodide 8 November 2018 Eleen Laul

Overview Uses: Physical properties: • Chemical reagent • Colourless liquid • Methylation • Odor: Pungent, ether-like • Grignard reagent preparation • Density: 2. 28 g cm-3 • Monsanto process (formed in situ) • Melting point: - 66. 5 ˚C • Pesticide? ! • Boiling point: 42. 4 ˚C • Vapour pressure: 54. 4 k. Pa 2

Toxicity Threats: • Acute toxicity (Dermal and oral contact, inhalation) • Target organ toxicity • Skin irritation • Suspected for carcinogenicity Symptoms: • Nausea, dizziness, headache, blurry vision, weakness, drowsiness etc. 3

Toxicity: mode of action DNA methylation Oxidative stress: • Apoptosis / necrosis • Nasal epithelium lesions GSH depletion Iodine accumulation Adenine Me. I Thyroid hormone level modulation: • Thyroid cancer Guanine Me. I Cytosine DNA Me-transferase • Irregular cytosine methylation is an important component in cancer development • However, limited proof of mutagenicity or carcinogenicity from Me. I DNA methylation 4

Handling Storage: Personal Equipment: • Dark bottles • to inhibit degradation to form I 2, which gives a purplish colour • Tight-fit goggles and a face shield • Cool, dry and well-ventilated place • Lab coat • Often stabilized by Cu or Ag wire • Air-purifying respirator (if necessary) • Gloves 5

First aid measures Inhalation: Fresh air, artificial breathing (if required) Skin contact: Wash with soap and plenty of water, take victim immediately to the hospital. Eye contact: Wash with plenty of water. If swallowed: Rinse mouth with water. 6

Thank you for your attention 7