Safety Efficacy Economic Convenience MRSA MRSA OR 95CI Slides: 49 Download presentation 合理用药 目标 Safety 安全 Efficacy Economic 有效 经济 Convenience 方便 MRSA感染的高危因素 MRSA感染高危因素的多因素回归分析 OR 95%CI P值 导管 7. 109 1. 983~25. 285 0. 002 近期接受抗菌治 疗 5. 078 1. 433~17. 999 0. 012 开放创口 6. 985 2. 710~18. 005 < 0. 001 皮质激素 4. 652 1. 0579~13. 709 0. 005 参数 BMC infect dis , 2011, 11: 303 产ESBLs菌株血行感染: 不同抗菌药物经验性治疗疗效比较 存活率 • 不同抗菌药物治疗方案30天病死 率比较 :Thirty-day mortality rates – 碳青霉烯类 12. 9% (8 of 62) – 头孢菌素 26. 9% (7 of 26) – 氨基糖苷类 26. 9% (7 of 26) 选择碳青霉烯类抗生素作 为产ESBLs菌株感染的经 验性治疗的合理性! Bloodstream Infections Due to Extended-Spectrum Beta-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae: Risk Factors for Mortality and Treatment Outcome, with Special Emphasis on Antimicrobial Therapy. AAC. 2004, 48, (12), p. 4574– 4581 多药联合治疗降低铜绿感染死亡率 100 90 80 死亡率 (%) 70 60 79. 41 68. 18 46. 51 50 40 26. 57 30 20 44. 44 40 联合用药 单药治疗 26. 83 26. 67 14. 29 13. 33 10 0 Tapper Hilf Mendelson Igra Kuikka Does combination antimicrobial therapy reduce mortality in Gram-negative bacteraemia A meta-analysis Lancet Infect Dis 2004; 4: 519– 27 Albert bandura self-efficacyPotency vs efficacyDrug efficacyLuminous efficacy comparison chartCollective teacher efficacyTypes of personality in organisational behaviourVaccine efficacyNebido effectivenessEfficacy therapyCollective teacher efficacyRole efficacyVaccine efficacySelf confidence modelEfficacy potencyCollective teacher efficacyTherapeutic indexDrug efficacyChristina mellonVreNozin mrsaDr david kim new england baptistMrsa infekceMru collective agreementMrsa woundRakkopistokatetriMrsa meddig fertőzCa mrsaMrsa de centroScabiesWhat is mrsa in medical termsMrsaMrsaMrsaEconomic growth vs economic developmentEconomic development vs economic growthChapter 1 lesson 2 our economic choices worksheet answersSafety contour safety depthBasic safety orientationQbs safety careBasic safety orientationProcess safety vs personal safetyInd safety reportVariety and assortment examplesVariety brandOne level distribution channelRich tudor foodQuota samplingAcom incCallbacksAccidental sampling adalah