Role of the clathrin adaptor PICALM in normal

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Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology by

Role of the clathrin adaptor PICALM in normal hematopoiesis and polycythemia vera pathophysiology by Yuichi Ishikawa, Manami Maeda, Mithun Pasham, Francois Aguet, Silvia K. Tacheva-Grigorova, Takeshi Masuda, Hai Yi, Sung-Uk Lee, Jian Xu, Julie Teruya. Feldstein, Maria Ericsson, Ann Mullally, John Heuser, Tom Kirchhausen, and Takahiro Maeda haematol Volume 100(4): 439 -451 March 31, 2015 © 2015 by Ferrata Storti Foundation

Picalm knockout mice develop microcytic and hypochromic anemia. Yuichi Ishikawa et al. Haematologica 2015;

Picalm knockout mice develop microcytic and hypochromic anemia. Yuichi Ishikawa et al. Haematologica 2015; 100: 439 -451 © 2015 by Ferrata Storti Foundation

Picalm is dispensable for myeloid and B-lymphoid development. Yuichi Ishikawa et al. Haematologica 2015;

Picalm is dispensable for myeloid and B-lymphoid development. Yuichi Ishikawa et al. Haematologica 2015; 100: 439 -451 © 2015 by Ferrata Storti Foundation

Inefficient erythroid development in Picalm. F/F Mx 1 Cre+ mice. Yuichi Ishikawa et al.

Inefficient erythroid development in Picalm. F/F Mx 1 Cre+ mice. Yuichi Ishikawa et al. Haematologica 2015; 100: 439 -451 © 2015 by Ferrata Storti Foundation

Tf. R endocytosis is impaired in Picalm-deficient erythroblasts. Yuichi Ishikawa et al. Haematologica 2015;

Tf. R endocytosis is impaired in Picalm-deficient erythroblasts. Yuichi Ishikawa et al. Haematologica 2015; 100: 439 -451 © 2015 by Ferrata Storti Foundation

Formation of clathrin-coated vesicles in Picalm-deficient cells. Yuichi Ishikawa et al. Haematologica 2015; 100:

Formation of clathrin-coated vesicles in Picalm-deficient cells. Yuichi Ishikawa et al. Haematologica 2015; 100: 439 -451 © 2015 by Ferrata Storti Foundation

PICALM/PIP 2 interaction is critical for erythroid differentiation. Yuichi Ishikawa et al. Haematologica 2015;

PICALM/PIP 2 interaction is critical for erythroid differentiation. Yuichi Ishikawa et al. Haematologica 2015; 100: 439 -451 © 2015 by Ferrata Storti Foundation

Picalm deletion ameliorates PV pathophysiology in mice. Yuichi Ishikawa et al. Haematologica 2015; 100:

Picalm deletion ameliorates PV pathophysiology in mice. Yuichi Ishikawa et al. Haematologica 2015; 100: 439 -451 © 2015 by Ferrata Storti Foundation