Rheumatoid Arthritis of the Cervical Spine Zikou Anastasia
- Slides: 34
Rheumatoid Arthritis of the Cervical Spine Zikou Anastasia Radiology Department University Hospital of Ioannina
Introduction Rheumatoid arthritis (RA) is a chronic multisystemic disease of unknown cause. Characteristic feature: inflammatory synovitis - peripheral joints / symmetrical distribution - cartilage destruction / bone erosion - joint deformity After the metacarpophalangeal joints, the most common region to be involved in RA is the cervical spine . History: 1890, *Garrod reported that 36% of his pts with RA had c-spine involvement. * Garrod, A. Griffins Medical Series. 1890. Available at: http: //books. google. Accessed July 11, 2011.
Introduction Radiographic signs: 43 -86% *Pellicci et al ( 5 yrs study / 106 RA pts) radiological evidence of c-spine involvement: 43% of pts / baseline 86% of pts / follow-up **Mikulowski et al: fatal cord compresion 10% in pts with RA Wasserman B, et al. Bull NYU Hosp for Jt Dis. 2011; 69(2): 136 -48. * Pellicci P et al. J Bone Joint Surg Am. 1981; 63: 342 -50. ** Mikulowski P et al. Acta Med Scand. 1975; 198(6): 445 -51.
Introduction ü Risk factors for c-spine involvement: – Males – RF - Rheumatoid nodules – Peripheral activity - Vasculitis – Corticosteroid use ü Clinical signs: – Neck pain 40 to 88% – Neurologic compromise 7 to 34% * Wasserman B, et al. Bull NYU Hosp for Jt Dis. 2011; 69(2): 136 -48
RA & C-Spine Imaging • Atlanto-axial subluxation ( 65% of all cervical subluxations ) - majority anterior - 20% lateral - 7% posterior - rotatory rare • Superior migration of the odontoid - second most common deformity - 20% of pts - odontoid erosions • Subaxial c-spine involvement - Subaxial subluxation : 15% of pts - Apophyseal joint ankylosis * Wasserman B, et al. Bull NYU Hosp for Jt Dis. 2011; 69(2): 136 -48
RA & C-Spine Imaging
RA & C-Spine Imaging Radiography ü Anterior atlantoaxial subluxation ü Vertical subluxation ü Subaxial spinal involvement - Subaxial subluxation Magnetic Resonance Imaging ü Pannus ü Spinal cord
RA & C-Spine Imaging Radiography üAnterior atlantoaxial subluxation (AAS) AAS : 50% of pts symptomatic The role of plain radiography is to establish whethere are risk factors for cord compression.
ü AAS - Anterior atlantodental interval (AADI) AADI > 3 -6 mm: early instability transverse lig. AADI > 6 mm transverse & alar lig. AADI > 9 mm surgical stabilization. AADI : yellow line
ü AAS Neutral Flexion AADI : yellow line
ü AAS - Posterior atlantodental interval (PADI) All cervical spinal levels - cord: 10 mm - CSF: 2 mm - dura: 2 mm - PADI > 14 mm (avoid cord compression) - spinal canal: 17 -29 mm at C 1 PADI : : red line PADI
ü AAS Neutral Flexion PADI : red line
ü Vertical subluxation
ü Vertical subluxation Mc. Gregor´s line - Odontoid tip > 4. 5 mm
ü Vertical subluxation Ranawat method (♂ > 15 mm & ♀ > 13 mm)
ü Vertical subluxation Clark’s stations
ü Vertical subluxation cervicomedullary angle ( normal range: 135° to 175°)
ü Odontoid erosions
ü Odontoid erosions
ü Subaxial subluxation Subluxation > 1 mm > 3, 5 mm !!! Cervical Height Index (CHI) - subluxations at multiple levels - loss of disk height - bony collapse - CHI < 2 (neurologic compromise)
ü Subaxial subluxation Zikou AK, et al. J Rheumatol 32: 801 -806, 2005.
ü Sudaxial spinal involvement • Apophyseal joints ( erosions - ankylosis) • Intervertebral disk - space narrowing • Irregularity of the subchondral margins of the vertebral bodies • Erosion and sclerosis • Corticosteroid - ischemic necrosis of bone - vertebral collapse
Zikou AK, et al. J Rheumatol 32: 801 -806, 2005.
RA & C-Spine Imaging Magnetic Resonance Imaging Major indications for c-spine MRI in RA: - abnormal measurements on plain radiographs - unremitting suboccipital /cervical pain - progressive / severe subluxations - symptoms of cord/brainstem/vert. art. compression MRI : evaluation of the spinal cord and neural elements - Presence and effect of pannus on the spinal cord - Spinal cord signal can be assessed (edematous spinal cord changes: poor clinical status, poor prognosis & poor postoperative outcome)
AAS “pannus”
Odontoid erosions - “pannus”
Odontoid erosions - “pannus” Zikou AK, et al. Clin Exp Rheumatol 23: 665 -670, 2005.
Subaxial subluxation Zikou AK, et al. Clin Exp Rheumatol 23: 665 -670, 2005.
AAS Subaxial subluxations
Brainstem compression - myelopathy
Take home messages Plain radiography : Flexion / extension views - the level of involvement - evidence of instability AADI > 9 mm or PADI < 14 mm Vertical subluxation Subaxial subluxation > 3, 5 mm Further imaging with MRI : pannus & spinal cord The major role for MRI : pre & after operative assessment
* 165 RA pts ( 143♀/ 22♂) mean age: 59, 6 ± 12, 5 yrs disease duration: 12, 3 ± 7, 9 yrs RF (+) : 63, 6% ** 51 RA pts ( 42♀/ 9♂) mean age: 56, 5 ± 10, 4 yrs disease duration: 12, 4 ± 8, 5 yrs RF (+) : 64, 7% clinical signs : c-pain & stiffness 30% Radiological findings: 146 pts - AAS: 20, 6% - Odontoid erosions: 2, 4% - Sudaxial subluxations: 43, 6% - Disk space narrowing: 66, 1% - Vertebral plate erosions - sclerosis: 43, 6% Rx / MR findings: 40 / 44 pts - Peridental pannus: 88% - Odontoid erosions: 23, 5% - AAS: 13, 7% - Brainstem compression: 5, 9% - Sudaxial subluxations: 10% C - spine involvement: frequent finding mild severity Peridental pannus correlated (p<0, 05) with: - DAS-28 - RF(+) - Erosive changes hand-wrist (Larsen criteria) *Zikou AK, et al. Radiological cervical spine involvement in patients with rheumatoid arthritis: a cross sectional study. J Rheumatol 32: 801 -806, 2005. **Zikou AK, et al. Magnetic resonance imaging findings of the cervical spine in patients with rheumatoid arthritis: a cross sectional study. Clin Exp Rheumatol 23: 665 -670, 2005.
- Barik meaning
- Steinbrocker stage
- Nail pitting
- What is subluxation
- Haart side effects
- Nursing management of rheumatoid arthritis
- Rheumatoid arthritis
- Ocular sign
- Nursing diagnosis for gouty arthritis
- Tofacitinib uveitis
- Rheumatoid arthritis
- Rheumatoid arthritis in hands
- Difference between osteoarthritis and rheumatoid arthritis
- Caplan syndrome
- Abatacept
- Reflexology tips
- Dr eugene lim
- Anastasia gorokhova
- Anastasia salinger
- Nick anastasia
- Anastasia fiandaca
- Anastasia kurdia
- How often do you play it
- Anastasia chalkidou
- Kyle ran into his house slamming the door behind him
- Anastasia yakimova
- Anastasia romanov story
- Anastasia phillips age
- What happened to anastasia
- Yandex ü
- Anastasia berezniak
- Arthritis and food allergies
- Peripheral arthritis
- Gout treatment
- Septic arthritis complications