RESVENOX TM Resveratrol Polyphenolic Antioxidant Discover Resveratrol its

RESVENOX TM Resveratrol. Polyphenolic. Antioxidant. Discover Resveratrol, its meaning and benefits. www. resvenox. com an ingredient of Sabinsa Corporation

What is Resveratrol? • Is a stilbenol, a derivative of stilbene, a natural product from plants. • Stilbenols are polyphenolic compounds that act as cancer chemopreventive agents 1. • RES exists as two geometrical isomers: cis(Z) and trans- (E). • Trans-resveratrol is the active form. 1. Fresco P, et al. Med Res Rev. 2006 Nov; 26(6): 747 -66

Resveratrol Offers Anti-Aging Benefits • Is a powerful compound found in certain food (such as red wines, grapes, and peanuts). • It has already been shown that RES extends the life of yeast, round worms, and mice 1. • RES found in red wine is responsible for the people of southern France having low incidences of coronary heart disease despite a high intake of saturated fats; and this is known as the “French Paradox. ” 1. Stipp, D. Can Red Wine Help You Live Forever? Fortune. Jan 19, 2007

Sirtuins • Resveratrol works with the sirtuin genes • The sirtuin genes appear to be responsible for preserving the lives of cells. • Sirtuin genes influence age related diseases cancer, heart disease, osteoporosis, diabetes and neurodegeneration 1, 2 1. Soleas GJ, Diamandis EP, Goldberg DM. Resveratrol: a molecule whose time has come? And gone? Clin Biochem. 1997 Mar; 30(2): 91 -113. 2. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol. 2006 Feb 7; 16(3): 296 -300

Declining Hormone Levels With Age • As we age, there is a natural decrease in estrogen androgen levels that leads to poor functioning of tissues and organs, which can increase the chances of cancer. • Hormone dependent tumors such as breast and prostate can be averted by daily consumption of selective estrogen receptor modulators (SERMs)1. 1. Signorelli P, Ghidoni R. J Nutr Biochem. 2005 Aug; 16(8): 449 -66

How Can Resveratrol Help? • Resveratrol is a polyphenol that acts as a phytoestrogen with positive effects on estrogen receptor-expressing and nonexpressing human tumors, and it can function as natural SERM 1. Signorelli P, Ghidoni R. J Nutr Biochem. 2005 Aug; 16(8): 449 -66

Cardiovascular Health Support • Antioxidant and anti-platelet activities of Resveratrol allow for it to function as a powerful heart protectant 1. • One study reported that treating rat heart cells called fibroblasts with resveratrol prevented the actions of the hormone angiotensin II 2. 1. Cal C, et al. Curr Med Chem Anticancer Agents. 2003 Mar; 3(2): 77 -93. 2. Olson ER, et al. Am J Physiol Heart Circ Physiol. 2005 Mar; 288(3): H 1131 -8

Free Radical Scavenging • Resveratrol has also been to shown to exert powerful inhibitory activity against superoxide anion and hydrogen peroxide production 1. • Has hydroxyl-radical scavenging properties and it has been found to have glutathionesparing activity 2. 1. Wu JM, et al. Int J Mol Med. 2001 Jul; 8(1): 3 -17 2. Burkitt MJ, et al. Arch Biochem Biophys. 2000; 381: 253 -263

Resveratrol VS. Glucocorticoids • Offers anti-inflammatory properties. • It was reported that RES was more effective, though less powerful than glucocorticoids 1. • Some of the applications of this study are that RES should be valuable in inflammatory diseases where glucocorticosteroids have proved to be unsuccessful, such as COPD, steroid-resistant asthma, and arthritis. 1. Donnelly LE, Am J Physiol Lung Cell Mol Physiol. 2004

Immune Support • Resveratrol interferes with all three stages of carcinogenesis – initiation, promotion and progression. • It was shown that Resveratrol can protect rodents from mammary cancer (breast cancer)1. Whitsett TG Jr, Lamartiniere CA. Genistein and resveratrol: mammary cancer chemoprevention and mechanisms of action in the rat. Expert Rev Anticancer Ther. 2006 Dec; 6(12): 1699 -706.

Immune Support • Resveratrol exerts antioxidant and antiinflammatory effects, and can potentially modulate cell death as well as cell cycle and estrogen receptor function in breast cancer cell lines 1. Le Corre L, Chalabi N, Delort L, Bignon YJ, Bernard-Gallon DJ. Resveratrol and breast cancer chemoprevention: molecular mechanisms. Mol Nutr Food Res. 2005 May; 49(5): 462 -71

Immune Support • Research shows that the oedemasuppressing activity of resveratrol is better than indomethacin or phenylbutazone 1. • Other research shows that RES can prevent the growth of leukemia cells in culture 2. 1. Jang M, et al. Science, 275, 218– 220 2. Tsan MF, et al. Leuk Lymphoma. 2002 May; 43(5): 983 -7

Sports Nutrition • A study found that mice fed Resveratrol had bigger and denser mitochondria amassed between adjacent myofibrils in their nonoxidative fibers 1 • The max VO 2 rate was much higher in the nonoxidative muscle fibers of mice given RES, which means there was an increased oxidative capacity. • VO 2 max is the maximum capacity to transport and utilize oxygen during incremental exercise 1. Lagouge M, et al. Cell. 2006 Dec 15; 127(6): 1109 -22

Sport Nutrition • Since RES has the possibility to change muscle fibers to a dominance of oxidative type 1 fibers, this would improve endurance due to the fact that these type of fibers have a higher resistance to muscle fatigue 1. • Mice given RES were shown to outrun the control group by almost twice the distance 1. 1. Lagouge M, et al. Cell. 2006 Dec 15; 127(6): 1109 -22

Resveratrol and Influenza • RES has some interesting anti-influenza properties 1. • An in vitro study found that RES profoundly inhibited influenza virus replication in cell cultures 1. • For mice it was shown that RES given after influenza infection increased survival by 40% compared to placebo. 1. Palamara AT, et al. J Infect Dis. 2005 May 15; 191(10): 1719 -29

Other Antiviral Effects • RES has also been shown to exhibit activity against herpes simplex virus types I and II 1 • The RES disturbs a crucial early event in the viral reproduction cycle. 1. Docherty JJ, et al. Antiviral Res. 1999 Oct; 43(3): 145 -55

Brain Health • Resveratrol has the special ability to modulate the mechanisms of neurological disease such as strokes, ischemia, Alzheimer’s, and Huntington's disease 1. • This occurs through the SIRT 1 protein. • A study found that mice with ischemia in the brain had improved blood flow from one dose of resveratrol 2 • The use of RES after brain injury has potential to reduce oxidative stress and lesion volume 3. 1. Brain Res Rev. 2006 Sep; 52(2): 316 -26 2. J Agric Food Chem. 2006 Apr 19; 54(8): 3126 -31 3. Mol Cell Biochem. 2007 Jan; 294(1 -2): 137 -44

Metabolic Health • RES can play a role in metabolic disease prevention such as obesity and diabetes • A study showed that when RES was given orally to mice it activated a protein in the Sirtuin family, which in turn activated another protein for mitochondrial function 1 • The study proved that RES increases the association of the Sirt 1 enzyme with energy expenditure, which therefore led to a reduction in weight gain. 1. Lagouge, M, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT 1 and PGC-1 alpha. Cell. 2006 127(6): 1109 -22

High Calories and Resveratrol • A study had three groups of mice: first group fed a high calorie diet, second group a normal diet, third group given RES along with a high calorie diet. • The results showed that when the high calorie fed mice reached old age (114 weeks), greater than 50% had died compared to less than 33% of the high calorie mice receiving resveratrol 1. 1. Baur JA, et al. Nature. 2006 Nov 16; 444(7117): 337 -42.

High Calories and Resveratrol • Results also showed that mice receiving RES had lower plasma levels of insulin, glucose and insulin-like growth factor (IGF) 1– all of which are markers for the onset of diabetes in humans if elevated 1. Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117): 337 -42

Resveratrol Simulates Calorie Restrictions • Calorie restrictions have been shown to lengthen lifespan in numerous animals by activating the SIRT 1 enzyme. • RES is one such compound that can activate the SIRT 1 and mimic the effects of calorie restriction 1 1. Baur JA, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006 Nov 16; 444(7117): 337 -42

Skin Health • Research has shown that RES applied topically can inhibit the expression of a cancer causing protein that is caused by UVB exposure (sun)1. • Resveratrol also has the ability to inhibit Propionibacterium acne growth 2 1. Reagan-Shaw, et al. Oncogene. 2004 Jul 1; 23(30): 5151 -60 2. Docherty JJ, et al. J Antimicrob Chemother. 2007 Apr 21

Skin Health • Another quality of RES is that when applied topically in sufficient quantities, it has the ability to prevent the growth of fungal infections known as dermatophytosis 1. Chan MM, et al. Biochem Pharmacol. 2002 Jan 15; 63(2): 99 -104

Cosmeceutical Applications • Because it possesses certain antifungal properties, resveratrol may have use in antifungal creams and ointments. • Useful in preparations used to rid one’s body of acne. • Applications for use in sunscreens, sunburn creams with aloe vera, and other beauty products.

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