Research Programme on Biomedical Informatics GRIB Ferran Sanz

Research Programme on Biomedical Informatics (GRIB) Ferran Sanz – GRIB

What is the GRIB? • GRIB is a research programme of both Universitat Pompeu Fabra (UPF) and IMIM. • IMIM is the research institute of. Hospital del Mar (PSM)and it is academically affiliated to the UPF. • GRIB is located in the Biomedical Research Park of Barcelona (PRBB). • GRIB is also the Biomedical Informatics node of the Spanish Institute of Bioinformatics (INB). Ferran Sanz – GRIB

GRIB Mission TICs and computational approaches are mandatory tools for managing and exploiting the immense amounts of data that are currently generated in the biomedical research (experimental, clinical, epidemiological). Mission: To invent, develop and apply computational methods that, through an intensive use of and information technologies, allow a better understanding and prediction of biological phenomena, giving especial emphasis to those related to the human diseases and their treatment.

GRIB themes and organisation GRIB is organised in six thematicin silico labs: Computational Genomics: Computational analysis of genomic sequences and information. PIs: M. Albà, E. Eyras, N. Lopez-Bigas & R. Castelo. Structural Bioinformatics: Analysis and modelling of protein structures and interactions. PI: B. Oliva. Computational Biochemistry and Biophysics: Modelling and simulation of biophysical and biochemical phenomena at molecular and systemic scales. IPs: J. Villà-Freixa and G. de Fabritiis. Chemogenomics: Computational annotation and analysis of massive molecular DBs vs. protein families showing therapeutic interest. IP: J. Mestres. Computer-Assisted Drug Design: Molecular modelling and multivariate statistical analysis in the drug R&D. IPs: M. Pastor, J. Selent & I. Zamora (part time) Integrative Biomedical Informatics: Integrative knowledge management in biomedical research. IP: F. Sanz. +Management office. Manager: C. Donlo Ferran Sanz – GRIB

The GRIB team The GRIB staff is a multidisciplinary team of +70 professionals (+20 Ph. Ds), which includes: • biologists, • pharmacists, • chemists, • physicians, • computer scientists, • mathematicians • research management staff Ferran Sanz – GRIB

GRIB research outcomes * Without including Complex System Lab. publications Ferran Sanz – GRIB

GRIB research outcomes • Average IF of the journals of GIB publications (2005 -09): 5. 33 • No. of citations of papers published in 2005 -07: 1668 Ferran Sanz – GRIB

GRIB research outcomes • GRIB develops open source and proprietary software that is internationally recognised. • GRIB research has generated two spin-off: • Pharmatools • Chemotargets Ferran Sanz – GRIB

Integrative knowledge management in pharmacovigilance 30 M EHRs from 4 EU countries ! • Literature mining • in silicosimulation • Pathway analysis • Genetic polymorphisms www. alert-project. org

Workflows for chemo- & bio-informatics signal substantiation Drug Possible drug – AE relationship to be assessed Adverse event Biologica l pathways Drug metabolites Involved proteins Similar drugs-ligands Genetic variants (SNPs)

GRIB’s strategic priority • The GRIB aims to enhance its biomedical focus, putting the emphasis in the clinical application of the bioinformatics and knowledge management approaches that it develops. • In particular, we are currently developing a strategic collaboration with Hospital del Mar (PSM)on the research exploitation of its clinical information system (IMASIS). Ferran Sanz – GRIB

grib. imim. es Ferran Sanz – GRIB