Reparative Effects of Stem Cell Factor and Granulocyte

Reparative Effects of Stem Cell Factor and Granulocyte Colony-Stimulating Factor in Aged APP/PS 1 Mice Guo Xingzhi, Liu Yanying, Morgan David, Zhao Li-Ru 1 Department of Neurosurgery, State University of New York Upstate Medical University, Syracuse, New York, 13210, USA 2 Translational Neuroscience, Michigan State University, College of Human Medicine, Grand Rapids, Michigan, 49503, USA Figure 10. Correlation between A&#x 003 B 2; plaques, homeostatic microglia, dendrites and synapses in the brains of aged APP/PS 1 mice treated with or without SCF+G-CSF. (A and B) P 2 RY 12 + homeostatic microglia show a significantly negative correlation with X-34 + fibrillar A&#x 003 B 2; plaques in the cortex (r = -0. 776, p&#x 0003 C; 0. 05) (A) and hippocampal CA 1 (r = -0. 712, p&#x 0003 C; 0. 05) (B). Note that increased P 2 RY 12 + Aging and Disease, 2020, 11(6), 1423 -1443. DOI: 10. 14336/AD. 2020. 0201 resting microglia are correlated with the reduced X-34 + fibrillar A&#x 003 B 2; plaques in the cortex and hippocampal CA 1 in the SCF+G-CSF-treated aged APP/PS 1 mice. (C and D) P 2 RY 12 + microglia display a positive correlation with MAP 2 + dendrites in the cortex (r=0. 831, p&#x 0003 C; 0. 01) (C) and hippocampal CA 1 (r=0. 663, p=0. 051) (D). Note that increased P 2 RY 12 + homeostatic microglia are correlated with the increased MAP 2 + dendrites in the cortex and CA 1 in the SCF+G-CSF-treated aged APP/PS 1 mice. (E and F) P 2 RY 12 + microglia show a significantly positive correlation with PSD-95 + puncta in the cortex (r=0. 854, p&#x 0003 C; 0. 01) (E) and hippocampal CA 1 (r=0. 928, p&#x 0003 C; 0. 001) (F). Note that the increased P 2 RY 12 + homeostatic microglia are