Relevance of platelet desialylation and thrombocytopenia in type
Relevance of platelet desialylation and thrombocytopenia in type 2 B von Willebrand disease: preclinical and clinical evidence by Annabelle Dupont, Christelle Soukaseum, Mathilde Cheptou, Frédéric Adam, Thomas Nipoti, Marc-Damien Lourenco-Rodrigues, Paulette Legendre, Valérie Proulle, Antoine Rauch, Charlotte Kawecki, Marijke Bryckaert, Jean-Philippe Rosa, Camille Paris, Catherine Ternisien, Pierre Boisseau, Jenny Goudemand, Delphine Borgel, Dominique Lasne, Pascal Maurice, Peter J. Lenting, Cécile V. Denis, Sophie Susen, and Alexandre Kauskot haematol Volume 104(12): 2493 -2500 December 1, 2019 © 2019 by Ferrata Storti Foundation
Platelet desialylation in human and murine type 2 B von Willebrand disease (v. WF) in vivo. Annabelle Dupont et al. Haematologica 2019; 104: 2493 -2500 © 2019 by Ferrata Storti Foundation
Platelet desialylation by 2 B von Willebrand disease (v. WF) in vitro occurs on N-glycans. Annabelle Dupont et al. Haematologica 2019; 104: 2493 -2500 © 2019 by Ferrata Storti Foundation
Type 2 B von Willebrand disease (v. WF) induces desialylation of the integrin αIIbβ 3. Annabelle Dupont et al. Haematologica 2019; 104: 2493 -2500 © 2019 by Ferrata Storti Foundation
Effect of platelet desialylation on the platelet count. Annabelle Dupont et al. Haematologica 2019; 104: 2493 -2500 © 2019 by Ferrata Storti Foundation
A threshold of platelet desialylation is required to affect the platelet count. Annabelle Dupont et al. Haematologica 2019; 104: 2493 -2500 © 2019 by Ferrata Storti Foundation
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