Regulation of IRF3 dependent Innate Immunity by the

Regulation of IRF-3 -dependent Innate Immunity by the Papain-like Protease Domain of the Severe Acute Respiratory Syndrome Coronavirus* Santhana G. Devaraj, Nan Wang, Zhongbin Chen, Zihong Chen, Monica Tseng, Naina Barretto, Rongtuan Lin, Clarence J. Peters, Chien -Te K. Tseng, Susan C. Baker, Kui Li Journal of Biological Chemistry Volume 282 Issue 44 Pages 32208 -32221 (November 2007) DOI: 10. 1074/jbc. M 704870200 Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 1 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 2 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 3 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 4 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 5 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 6 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 7 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 8 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions

FIGURE 9 Journal of Biological Chemistry 2007 28232208 -32221 DOI: (10. 1074/jbc. M 704870200) Copyright © 2007 ASBMB. Currently published by Elsevier Inc; originally published by American Society for Biochemistry and Molecular Biology. Terms and Conditions