Recurrent deletions of IKZF 1 in pediatric acute

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Recurrent deletions of IKZF 1 in pediatric acute myeloid leukemia by Jasmijn D. E.

Recurrent deletions of IKZF 1 in pediatric acute myeloid leukemia by Jasmijn D. E. de Rooij, Eva Beuling, Marry M. van den Heuvel-Eibrink, Askar Obulkasim, André Baruchel, Jan Trka, Dirk Reinhardt, Edwin Sonneveld, Brenda E. S. Gibson, Rob Pieters, Martin Zimmermann, C. Michel Zwaan, and Maarten Fornerod haematol Volume 100(9): 1151 -1159 September 4, 2015 © 2015 by Ferrata Storti Foundation

Patients’ characteristics of IKZF 1 deleted pediatric AML cases (n=11). Jasmijn D. E. de

Patients’ characteristics of IKZF 1 deleted pediatric AML cases (n=11). Jasmijn D. E. de Rooij et al. Haematologica 2015; 100: 11511159 © 2015 by Ferrata Storti Foundation

Heterozygous IKZF 1 deletions in pediatric AML. (A) Multiplex ligation-dependent probe amplification results of

Heterozygous IKZF 1 deletions in pediatric AML. (A) Multiplex ligation-dependent probe amplification results of a patient with heterozygous deletion of exons 1– 8 of IKZF 1 including the reference probe in POR located on 7 q 11. 23. Jasmijn D. E. de Rooij et al. Haematologica 2015; 100: 11511159 © 2015 by Ferrata Storti Foundation

Array comparative genomic hybridization analysis of monosomy 7 and focal IKZF 1 deletions. Jasmijn

Array comparative genomic hybridization analysis of monosomy 7 and focal IKZF 1 deletions. Jasmijn D. E. de Rooij et al. Haematologica 2015; 100: 11511159 © 2015 by Ferrata Storti Foundation

IKZF 1 haploinsufficient acute myeloid leukemia (AML) cells display an AML-specific gene expression signature.

IKZF 1 haploinsufficient acute myeloid leukemia (AML) cells display an AML-specific gene expression signature. Jasmijn D. E. de Rooij et al. Haematologica 2015; 100: 11511159 © 2015 by Ferrata Storti Foundation

Monosomy 7 and focal IKZF 1 deletion associate with gene expression profiles with significant

Monosomy 7 and focal IKZF 1 deletion associate with gene expression profiles with significant similarity. Jasmijn D. E. de Rooij et al. Haematologica 2015; 100: 11511159 © 2015 by Ferrata Storti Foundation

HEMGN, FHL 2, FZD 6 and SETBP 1 expression in IKZF 1 -deleted patients

HEMGN, FHL 2, FZD 6 and SETBP 1 expression in IKZF 1 -deleted patients as compared to other cytogenetically classified AML groups. Jasmijn D. E. de Rooij et al. Haematologica 2015; 100: 11511159 © 2015 by Ferrata Storti Foundation

Genes commonly up-regulated in IKZF 1 focally deleted and monosomy 7 cases are enriched

Genes commonly up-regulated in IKZF 1 focally deleted and monosomy 7 cases are enriched in myeloid GATA 1 targets. Jasmijn D. E. de Rooij et al. Haematologica 2015; 100: 11511159 © 2015 by Ferrata Storti Foundation