Receptor Tyrosine Kinase Family Receptor tyrosine kinases RTK

Receptor Tyrosine Kinase Family Receptor tyrosine kinases (RTK) 1. 2. 3.

Receptor Tyrosine Kinases Receptor tyrosine kinases (RTK) 1. 2. 3. 4. 5.

Receptor Tyrosine Kinases GHR VEGFR 3 examples of how ligand interacts with receptors 1. 2. 3. FGFR Brooks et al 2014 Science 344: 703; Hagberg C et al 2013. Physiol 28: 125

Receptor Tyrosine Kinase Heterodimers Receptor tyrosine kinase heterodimers: The EGFR family 1. 2. 3. 4. 5.

Receptor Tyrosine Kinase Activation of Signaling RTK activation of signaling 1. 2. 3. 4. 5.

Protein: Protein Interaction Domains Protein: Protein interaction domains: Domains that interact with receptors 1. SH 2 (Src homology 2): 2. PTB (phosphotyrosine binding): Protein interaction domains 1. PH (pleckstrin homology): 2. SH 3: 3. WW: 4. PDZ: 5. FYVE:

Docking Proteins

Receptor Tyrosine Kinase Activation of Signaling Conformational Change Example: Activation of PI 3 -Kinase by conformational change 1. 2. 3. 4. 5.

Receptor Tyrosine Kinase Activation of Signaling Membrane translocation Example: Activation of PKB (Akt) by PDGF 1. 2. 3. 4. 5.

Receptor Tyrosine Kinase Activation of Signaling Tyrosine phosphorylation Example: Activation of Phospholipase Cg by EGFR, PDGFR or FGFR 1. 2. 3.

Receptor Tyrosine Kinase Activation of Signaling pathways activated by RTK signaling 1. 2. 3. 4. 5.

MAP Kinase signaling pathways MAP Kinase Signaling 1. MAPKKK MAPKK 2. 3. MAPK 4. 5. 6. Mitogen Activated Kinase Families 1. 2. 3. 7.

AKT signaling pathways PKB/Akt Signaling 1. 2. 3. 4. 5. 6.

RTK signaling example: Insulin Receptor (IR) Signaling 1. 2. 3. 4. 5.