RealWorld Data Understanding What Really Happens to a

Real-World Data: Understanding What Really Happens to a Patient

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Objectives • Increase advanced practitioners’ awareness and understanding of realworld data (RWD) and real-world evidence (RWE) • Define the concept of the efficacy-effectiveness gap in oncology/hematology practice • Discuss emerging real-world data in hematology/oncology and real-world evidence data gaps • Understand the benefits and challenges posed by real-world data • Develop ways to apply real-world data to clinical practice 3

What Is Real-World Data? • Real-world data (RWD) is information collected during standard clinical care or billing that is synthesized and/or analyzed to create real-world evidence (RWE) • Data on the effects of health interventions (such as benefits, risks or resource use) that are not collected in the context of conventional randomized controlled trials (RCTs). • The data generated from RWD reflect a broader, more diverse patient population. Bolislis, W. R. , et al. Clinical Therapeutics, 2020; 42(5): 926 -938; Moran, M. , et al. Future Oncology, 2019; 15(34): 3987 -4001; RWE Navigator. Get Real. 2021. https: //rwe-navigator. eu/use-real-worldevidence/sources-of-real-world-data/ 4

Contributors LEAD AUTHOR Amy Pierre, MSN, ANP-BC Memorial Sloan Kettering Cancer Center, Montvale, New Jersey Clinical Director, Flatiron Health, New York REVIEWERS Maritza Cardena Alencar, DNP, MBA, APRN-BC, BMTCN® Miami Cancer Institute Miami, Florida Val R. Adams, Pharm. D, BCOP, FCCP, FHOPA University of Kentucky Lexington, Kentucky 55