Radia 7887 Cold Waterinoil emulsifier INCI Polyglycerol3 Polyricinoleate

Radia 7887 Cold Water-in-oil emulsifier

INCI: Polyglycerol-3 Polyricinoleate & Sorbitan Isostearate HLB 4, 2 & Single Emulsifier Liquid & EO Free Amber Coloured

1. W/O Properties 2. W/O Applicatio ns 1. W/O Properties • Skin protection 3. Famous Examples • Long lasting moisturisation 4. R 7887 • Resemblance to the natural skin protective barrier 5. Formulatio ns • Improved spreading and penetration of active ingredients • Reduced preservative concentration

1. W/O Properties 2. W/O Applicatio ns 2. W/O Applications • Sun Screen milks, lotions and creams 3. Famous Examples • Night creams 4. R 7887 • Creams & lotions for dry and sensitive skin 5. Formulatio ns • Skin protective baby creams • Massage milks

1. W/O Properties 2. W/O Applicatio ns 3. Famous examples 4. R 7887 5. Formulatio ns 3. Famous Examples Multi purpose cream Body Milk Sunscreen Diaper cream

1. W/O Properties 2. W/O Applicatio ns 4. R 7887. . • . . . is liquid and allows cold production = reduced cost! 3. Famous examples • . . . is based on natural raw materials & is PEG free. 4. R 7887 • . . . has no need for co-emulsifier single emulsifier 5. Formulatio ns • …is fit for high and low internal face • . . . provides emulsions with a glossy appearance • …functions at low levels (≥ 1%)

1. W/O Properties 2. W/O Applicatio ns 3. Famous examples 4. R 7887 5. 6. 7. 8. • Solid emulsifier requires temperature (=cost) input. T (°C) 1 2 Hot Process +/- 80 a. Cold Process b. Emollients c. Single Emulsifier 5. Form ulations 3 4 = Cost 20 Homogenize 5

1. W/O Properties 2. W/O Applicatio ns 3. 4. 5. 6. 7. 8. • R 7887 doesn’t require heating = possible cost reduction! T(C°) Famous examples 1 R 7887 2 3 4 Homogenize a. Cold Process b. Emollients c. Single Emulsifier 5. Form ulations 20 5

1. W/O Properties 2. W/O Applicatio ns 3. Famous examples • Potential cost reduction thanks to cold proces. Hot Proces vs Cold Proces Weighing and mixing Weighing mixing Heating Homogenisation Addition of other raw materials Cooling & agitation Filling 4. R 7887 5. a. Cold Process b. Emollients C. Single Emulsifier Time loss during cooling / Addition of other raw materials / Cooling to room tempurature / 5. Filling / 6. 7. 8. Form ulations Minutes 20 40 60 80 100 120 140 160

1. W/O Properties 2. W/O Applicatio ns 3. Famous examples 4. R 7887 a. Cold Process b. Emollients c. Single Emulsifier 5. Form ulations b. Emollients influence formulation. • % water => Viscosity Formulation • Viscosity emollients • Homogenisation => Viscosity Formulation => Stability (& Viscosity) Formulation

1. 2. W/O Properties W/O Applicatio ns c. Single Emulsifier. : Test protocol Test formulation W/O Oilphase 3. Famous examples Oil Emulsifier 4. R 7887 Waterphase 5. a. Cold Process b. Emollients c. Single Emulsifier Glycerol Mg. SO 4. 7 H 2 O Preservative Water 6. 7. 8. 5. Form ulations 10 or 18 or 30 1 or 3. 5 4 0, 7 q. s. to 100% Low external phase = 10% High external phase = 30% Low surfactant = 1% High surfactant = 3. 5% Centrifuge stability (3 x 15 min @ 4000 rpm) Temperature stability 1 week @ 50°C 2 months@ 40°C 3 months@ RT Viscosity stability ( m. Pas) Brookfield 10 rpm, 1 minute, LVT spindle After 1 day After 3 months appearance Visual aspect

1. W/O Properties 2. W/O Applicatio ns 3. Famous examples 4. R 7887 a. Cold Process b. Emollients c. Single Emulsifier 5. Form ulations c. Single Emulsifier. : Conclusions • 1% emulsifier is stable for MCT and paraffin oils (18%). • 3, 5% emulsfier is stable for MCT, sunflower oil and paraffin oils. Separate esters are being tested. • Highest viscosity and synergy is obtained by using sunflower oil. • Internal phases till 82% were achieved.

5. Formulations Low Cost W/O protective cream HP 11 -22 -2 • Phase • Ingredient • INCI • A • Radia 7887 • Polyglycerol-3 Polyricinoleate & Sorbitan Isostearate • 3. 6 • Radia 7373 • Triisostearin • 0. 5 • Radia 7363 • Triolein (= Sunflower oil) • 18 • Glycerin 4810 • Glycerin • water • Aqua • B • C • % w/w • 4 • To 100 • Mg. SO 4. 7 H 2 O • 0. 8 • preservative • 0. 7 Viscosity : 121000 m. Pa. s (Brookfield RV, spindle 7, rpm 10, 1 min. ) Assessment: Rich protective cream, high viscosity, film forming , good spreading

5. Formulations W/O soft body cream/Lotion HP 03 -54 -3 • Phase • Ingredient • INCI • A • Radia 7887 • Polyglycerol-3 Polyricinoleate & Sorbitan Isostearate • 4 • Radia 7208 • Propylene Glycol Dicaprylate/Dicaprate • 2 • Radia 7732 • Isopropyl Palmitate • B • C • % w/w • 11 • Sweet almond oil • 2 • Avocado oil • 2 • Glycerin 4810 • Glycerin • water • Aqua • 3 • To 100 • Mg. SO 4. 7 H 2 O • 0. 5 • preservative • 0. 7 • Viscosity , 35000 m. Pa. s (Brookfield RV, spindle 6, rpm 10, 1 min. ) • Assessment: Rich day lotion, nice, soft skinfeel, smooth afterfeel , good spreading

5. Formulations Low Cost Protective baby cream • Phase • Ingredient • INCI • A • Radia 7887 • Polyglycerol-3 Polyricinoleate & Sorbitan Isostearate HP 11 -12 -1 • Paraffin Oil • B • C • % w/w • 3, 6 • 15 • Radia 7373 • Triisostearin • 0, 5 • Radia 7500 • Cetyl Palmitate • 2 • Glycerin 4810 • Glycerin • 3 • water • Aqua • To 100 • Mg. SO 4. 7 H 2 O • 0. 5 • preservative • 0. 7 • Zn. O • 10 • Viscosity , 35000 m. Pa. s (Brookfield RV, spindle 6, rpm 10, 1 min. ) • Assessment: Rich day lotion, nice, soft skinfeel, smooth afterfeel , good spreading