Rabin Cone Contrast Test Eye Disease Detection and

Rabin Cone Contrast Test Eye Disease Detection and Monitoring 8330 S. Madison St. , Ste 60 Burr Ridge, IL 60527 630. 920. 8880 Cheryl@Innova. Systems. USA. com

Rabin Cone Contrast Test Detects Changes Associated with Eye and Neurological Disease, Potentially Aiding the Preservation of Eyesight and Reducing the Overall Cost of Healthcare

• A Color Vision Test Sensitive Enough to Detect Severity of Cone Deficiency • Can Determine Hereditary & Acquired Color Deficiency in a Single Test • Used to Detect & Monitor Acquired Color Deficiency in Eye Disease & Poor Retinal Health AMD Glaucoma Diabetic Retinopathy MS Parkinson’s Disease Retinal Toxicity due to High Risks meds such as Plaquenil o Macular Pigment Density loss o o o

Rabin Cone Contrast Test • Colored letters stimulate single cone types • Decreasing contrast steps detects cone function threshold • Numeric scores provide Hereditary vs. Acquired information • Comparisons detects significant changes in function

Achievements • 15 Years of US Air Force research • Published, Peer Reviewed • Validated against Anomaloscope • Approved as Sole Color Vision Test for US Air Force • Over 400 in Use Worldwide

Color Normals vs. Deficients 66

Custom Calibration • Calibrated for color and contrast • Detects sub-standard monitors & end-of-life color meters • Scheduled in-field calibration adapts to clinic or research • Ensures validity and repeatability of results

Rabin Cone Contrast in Eye Disease Acquired Color Deficiency 100 75 50 25 0 Red Green Blue

Acquired Color Deficiency in Central Serous Retinopathy Blue (Tritan) Red cone Normal Green cone Eye Blue RE & LE 20/20 Red cone Central Serous Green cone Blue 0 normal range 0. 5 1 1. 5 RCCT Log Score 2 2. 5

Acquired Color Deficiency in Optic Neuritis (Blue – Tritan) RE (20/15 VA) 5 line decrease Normal 2 SDs mean LE (20/15 VA) 0 20 40 60 80 100 Blue Cone RCCT Score Resolved Optic Neuritis Right Eye • Tritan Defect • MRI & CSF— • Probable MS

Current Research • Military - Cases of Optic Neuropathy o o Identified with Rabin Cone Contrast Test that was missed by all other equipment. Cone recovery shown with RCCT • Military – Central Serous Retinopathy • Military – Traumatic Brain Injury o • Duke University - Dry. AMD o o • Identified with RCCT Clinical Trial results: the AREDS 3 intermediate AMD group exhibited visual dysfunction on the Rabin Cone Contrast Test, in the presence of normal visual acuity Phase II clinical trial begins fall 2014 Case studies – Macular Pigment Density o o Reduced Rabin Cone Contrast scores with low macular pigment density loss Identified prior to OCT and visual acuity changes

Patient Benefit • Identification of patients at-risk for developing disease • Earlier recognition and intervention of disease • Rapid detection of disease progression • Evaluation of treatment efficacy Improved Quality of Care

Financial Benefit • Increases Medicare billings for 92283 - Extended Color Vision Exam • Drives Medicare billings of structural diagnostic equipment • Increases clinic economic throughput by identifying patients most in need of care $ Increased Per-Patient Revenue