QT Fabio Badilini Ph D AMPS LLC New

在屏方式的QT间期测量法 Fabio Badilini, Ph. D AMPS LLC New York, NY 施根灵 译 1

比较不同的方法 第一种测试 QTc. F (msec) Sotalol 160 mg p = 0. 033 p = 0. 035 p = 0. 027 p < 0. 01 p = 0. 034 19 p = 0. 042 p = 0. 023 p < 0. 01 Badilini et al. (6)

可以进行样本之间的测量吗? 250 Hz Example QT = 376 (multiple of 4 msec) QT = 374 (NON multiple of 4 msec) 主张 2 ms的分辨率有错吗? 31

参考文献 1. International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). E 14 Guidance on clinical evaluation of QT/QTc interval prolongation and proarrhythic potential for non-antiarrythmic drugs. 2005 Available from URL: http: //www. fda. gov/cder/guidance/6922 fnl. pdf 2. Stockbridge N, Throckmorton DC. Regulatory advice on evaluation of the proarrhythmic potential of drugs. J Electrocardiol 2004; 37 (Suppl. ): 40 -41. 3. Stockbridge N, Brown, BD. Annotated ECG waveform data at FDA. J Electrocardiol 2004; 37 (Suppl. ): 83 -84. 4. Points to Consider: the assessment of the potential for QT interval prolongation by noncardiovascular medicinal products. Committee for Proprietary Medicinal Products (CPMP), London, 17 December 1997. 5. Murray A, Mc. Laughlin NB, Bourke JP, Doig JC, Furniss SS, Campbell RWP. Errors in manual measurement of QT intervals. Br Heart J 1994; 71: 386 -390 6. Badilini F, Sarapa N. Implications of Methodological Differences in Digital Electrocardiogram Interval Measurement. J Electrocardiol 2006; 39: S 152 -156. 7. Kligfield P, Tyl B, Maarek M, Maison-Blanche P. Magnitude, Mechanism, and Reproducibility of QT Interval Differences Between Superimposed Global and Individual Lead ECG Complexes. A. N. E. 2007; 12(2): 145 -152. 8. Malik M. Errors and Misconceptions in ECG Measurements Used for the Detection of Drug Induced QT Interval Prolongation. J Electrocardiol 2004; 37: S 25 -33. 34