Psychopharmacology Chapter 4 PsychoPharmacology q The hope to

Psychopharmacology Chapter 4

Psycho-Pharmacology q The hope: to change and cure psychic functions. q The means: target drugs. q Non-specific drugs work on mechanisms common to many neurons: ion channels, release of neurotransmitter, second messengers, etc. q Specific drugs work on mechanisms which differentiate between neurons: receptors, uptake, enzymes, etc.

Placebo effect

Effects of drugs on synaptic transmission

- receptor קולטן

Cocain (ritalin) effects on DA reuptake (9)

Drug effects on receptors

Presynaptic receptors

Autoreceptors

Effect of drugs acting through receptors

Biosynthesis of the catecholamines OH H OH

Biosynthesis of serotonin (5 -HT) HO CH 2

DA distribution in the brain

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