Proteins Structures Primary Structure Proteins Primary Structure Proteins

Proteins Structures • Primary Structure

Proteins • Primary Structure

Proteins • Sequence of Amino Acids

Proteins • Primary Structure

Proteins • Secondary Structure - Alpha Helix

Secondary Structure of Proteins • Alpha Helix - hydrogen bonds between amide groups.

Secondary Structure of Proteins • Alpha Helix - hydrogen bonds between amide groups.

Proteins • Secondary Structure

Secondary Structure Proteins • Pleated sheet - hydrogen bonds between chains

Shape from Bends, Folds and Loops • Tertiary Structure

Tertiary Structure of Proteins • Hydrogen bonding between side chains • Salt Bridges between side chains

Tertiary Structure of Proteins • Disulfide bonds between the cysteine - SH

Tertiary Structure of Proteins • Hydrophobic - non-polar interactions

Proteins • Primary Structure

Quaternary Structure of Proteins

Quaternary Structure of Proteins • Interaction of two or more chains • Collagen - triple helix

Quaternary Structure of Proteins • Interaction of two or more chains • Insulin - two chains bonded by disulfide

Quaternary Structure of Proteins • Interaction of two or more chains • Insulin - two chains bonded by disulfide

Globular Proteins • Heme and Myoglobin

Globular Proteins • Heme and Myoglobin

Globular Proteins • Hemoglobin - 4 chains, 4 heme groups

Protein Structure • Review the four kinds of structure - simple definitions.

Proteins • Primary Structure

Hydrolysis breaks primary sequence by splitting into amino acids • Review the four kinds of structure - simple definitions.

Denaturation • Review the four kinds of structure - simple definitions.

Denaturation • Review the four kinds of structure - simple definitions.

Denaturation • Disrupt Hydrogen Bonding - alcohol

Denaturation • Disrupt salt bridges - acids and bases

Denaturation • Disrupt disulfide bonds - reducing agents, heavy metals.