Protein sequences alignment and protein modeling Protein sequences

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Protein sequences alignment and protein modeling 唐世杰老師實驗室: 廖吉隆

Protein sequences alignment and protein modeling 唐世杰老師實驗室: 廖吉隆

Protein sequences alignment

Protein sequences alignment

• Proteins sharing a significant degree of sequences similarity and structural resemblance are

• Proteins sharing a significant degree of sequences similarity and structural resemblance are said to be homologous. PNAS (2000, 97, 8762 -8769)

The amino acid sequences of human hemoglobin, Bos taurus and Mus musculus show a

The amino acid sequences of human hemoglobin, Bos taurus and Mus musculus show a strong degree of homology.

• If same kind of proteins share homology, it can be revealed through

• If same kind of proteins share homology, it can be revealed through alignment of their sequence is using powerful computer programs. 1. Vector. NTI 2. Genedoc • We can use protein sequence alignment to search unknown protein you interesting.

• Protein sequence databases provide enormous resources for sequence comparisons. 1. National Center

• Protein sequence databases provide enormous resources for sequence comparisons. 1. National Center for Biotechnology Information (NCBI) 2. Expert Protein Analysis System (Ex. PASy)

Protein modeling

Protein modeling

• SWISS-MODEL is a fully automated protein structure homology-modeling server, accessible via the

• SWISS-MODEL is a fully automated protein structure homology-modeling server, accessible via the Ex. PASy web server. • The purpose of this server is to make Protein Modelling accessible to all biochemists and molecular biologists worldwide.

Alignment Unknown protein structure Modeling Similar protein sequence

Alignment Unknown protein structure Modeling Similar protein sequence

(1) PI 3 K (2) P 21 (3) P 53 (4) GAPDH (5) NF-k.

(1) PI 3 K (2) P 21 (3) P 53 (4) GAPDH (5) NF-k. B (6) Caspase 8 (7) AMPK (8) Topoisomerase (9) DNA helicase (0) Hemoglobin

Standard 7 Alignment Utah Model Alignment Vertical AlignmentStandard 7 Alignment Utah Model Alignment Vertical Alignment
Alignment Most alignment programs create an alignment thatAlignment Most alignment programs create an alignment that
LCLSII cryomodule alignment LCLSII cryomodule alignment Topics AlignmentLCLSII cryomodule alignment LCLSII cryomodule alignment Topics Alignment
Ontology Alignment Ontology Alignment n n Ontology alignmentOntology Alignment Ontology Alignment n n Ontology alignment
Alignment Most alignment programs create an alignment thatAlignment Most alignment programs create an alignment that
Ontology Alignment Ontology Alignment n n Ontology alignmentOntology Alignment Ontology Alignment n n Ontology alignment
Multiple Sequence Alignment Multiple Alignment versus Pairwise AlignmentMultiple Sequence Alignment Multiple Alignment versus Pairwise Alignment
Pairwise sequence Alignment Types of Alignment Global alignmentPairwise sequence Alignment Types of Alignment Global alignment
A Subquadratic Sequence Alignment Algorithm Global alignment AlignmentA Subquadratic Sequence Alignment Algorithm Global alignment Alignment
Alignment of large genomic sequences Fragmentbased alignment approachAlignment of large genomic sequences Fragmentbased alignment approach
Sequence Alignment n Global Alignment compare two sequencesSequence Alignment n Global Alignment compare two sequences
Bioinformatics Sequences alignment Sequence Alignment Practical Presented byBioinformatics Sequences alignment Sequence Alignment Practical Presented by
Bioinformatics Sequences alignment Sequence Alignment Practical Presented byBioinformatics Sequences alignment Sequence Alignment Practical Presented by
Investigating Sequences and Series Arithmetic Sequences Arithmetic SequencesInvestigating Sequences and Series Arithmetic Sequences Arithmetic Sequences
Investigating Sequences and Series Arithmetic Sequences Arithmetic SequencesInvestigating Sequences and Series Arithmetic Sequences Arithmetic Sequences
Geometric Sequences and Series Arithmetic Sequences Geometric SequencesGeometric Sequences and Series Arithmetic Sequences Geometric Sequences
Arithmetic Sequences and Geometric Sequences Arithmetic Sequences AnArithmetic Sequences and Geometric Sequences Arithmetic Sequences An
Arithmetic Sequences and Geometric Sequences Arithmetic Sequences AnArithmetic Sequences and Geometric Sequences Arithmetic Sequences An
Maths Unit 10 Sequences Picture sequences Sequences canMaths Unit 10 Sequences Picture sequences Sequences can
Sequences Notes Day 1 Arithmetic Sequences Sequences thatSequences Notes Day 1 Arithmetic Sequences Sequences that
Arithmetic Sequences Series Geometric Sequences Series Infinite SequencesArithmetic Sequences Series Geometric Sequences Series Infinite Sequences
Protein sequencing Determining protein sequences Why the proteinProtein sequencing Determining protein sequences Why the protein
Truncation of Protein Sequences for Fast Profile AlignmentTruncation of Protein Sequences for Fast Profile Alignment
Aligning Grass Protein Sequences Using PAMModified Global AlignmentAligning Grass Protein Sequences Using PAMModified Global Alignment