PROTEIN ENGINEERING Loschmidt Laboratories Enantis Ltd LOSCHMIDT LABORATORIES
PROTEIN ENGINEERING Loschmidt Laboratories Enantis, Ltd.
LOSCHMIDT LABORATORIES & ENANTIS q 17 years experience in protein science q multi-disciplinary team
LOSCHMIDT LABORATORIES & ENANTIS q 17 years experience in protein science q multi-disciplinary team q laboratories and facilities (1. 5 mil EUR) University Campus and Biotechnology Incubator, Brno
LOSCHMIDT LABORATORIES & ENANTIS q 17 years experience in protein science q multi-disciplinary team q laboratories and facilities (1. 5 mil EUR) University Campus and Biotechnology Incubator, Brno § molecular biology and microbiology
LOSCHMIDT LABORATORIES & ENANTIS q 17 years experience in protein science q multi-disciplinary team q laboratories and facilities (1. 5 mil EUR) University Campus and Biotechnology Incubator, Brno § molecular biology and microbiology § bioinformatics and molecular modelling
LOSCHMIDT LABORATORIES & ENANTIS q 17 years experience in protein science q multi-disciplinary team q laboratories and facilities (1. 5 mil EUR) University Campus and Biotechnology Incubator, Brno § molecular biology and microbiology § bioinformatics and molecular modelling § biochemistry and biophysics
LOSCHMIDT LABORATORIES & ENANTIS BIOSENSING BIOCATALYSIS DECONTAMINATION
DEVELOPMENT OF BIOCATALYTIC PROCESS
DEVELOPMENT OF BIOCATALYTIC PROCESS § GENETIC DATABASES § EXTREMOPHILES
DEVELOPMENT OF BIOCATALYTIC PROCESS § DIRECTED EVOLUTION resistance to organic solvents
DEVELOPMENT OF BIOCATALYTIC PROCESS § DIRECTED EVOLUTION § RATIONAL DESIGN thermostability enhancement
DEVELOPMENT OF BIOCATALYTIC PROCESS § DIRECTED EVOLUTION § RATIONAL DESIGN thermostability enhancement
DEVELOPMENT OF BIOCATALYTIC PROCESS § DIRECTED EVOLUTION § RATIONAL DESIGN thermostability enhancement 20°C
DEVELOPMENT OF BIOCATALYTIC PROCESS § OPTIMIZED EXPRESSION § FERMENTATION § DOWN STREAM
DEVELOPMENT OF BIOCATALYTIC PROCESS § MEDIUM ENGINEERING § IMMOBILISATION
HOTSPOT WIZARD RCSB PDB user Hot Spot Wizard
HOTSPOT WIZARD Uni. Prot RCSB PDB user CSA Hot Spot Wizard PDBSWS
HOTSPOT WIZARD Uni. Prot RCSB PDB user CSA Hot Spot Wizard PDBSWS CASTp CAVER
HOTSPOT WIZARD Uni. Prot RCSB PDB CSA PDBSWS Hot Spot Wizard user Rate 4 Site MUSCLE tunnels BLAST NRDB CASTp CAVER Cd-hit
HOTSPOT WIZARD mutability low high
HOTSPOT WIZARD haloalkane dehalogenase PDB-ID 1 BN 6 1, 3 -1, 4 -b-glucanase PDB-ID 1 GBG b-lactamase PDB-ID 1 BLS phosphotriesterase PDB-ID 1 I 0 D
HOTSPOT WIZARD + Proportion of mutations 1 positive and neutral 0. 8 0. 6 hot spots region 0. 4 0. 2 0 9 8 7 6 5 4 Estimated mutability 3 2 1
HOTSPOT WIZARD Proportion of mutations 1 positive and neutral slightly negative 0. 8 0. 6 hot spots region 0. 4 0. 2 0 9 8 7 6 5 4 Estimated mutability 3 2 1
HOTSPOT WIZARD Proportion of mutations 1 positive and neutral slightly negative deleterious 0. 8 0. 6 hot spots region 0. 4 0. 2 0 9 8 7 6 5 4 Estimated mutability 3 2 1
HOTSPOT WIZARD Pavelka et al. Nucl. Acids Res. 37: W 376 2009
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