Prostate Pathology Part 1 Francisco G La Rosa

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Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology

Prostate Pathology Part 1 Francisco G. La Rosa, MD Associate Professor, Department of Pathology University of Colorado Denver, Aurora, Colorado

NORMAL ANATOMY

NORMAL ANATOMY

SAGITAL SECTION OF THE PROSTATE GLAND Seminal Vesicle Central Zone Bladder Peri-urethral zone Transition

SAGITAL SECTION OF THE PROSTATE GLAND Seminal Vesicle Central Zone Bladder Peri-urethral zone Transition Zone Peripheral Zone Anterior Zone Fibro-muscular Urethra

3 D VIEW OF THE PROSTATE

3 D VIEW OF THE PROSTATE

3 D VIEW OF THE PROSTATE

3 D VIEW OF THE PROSTATE

CROSS SECTION OF THE PROSTATE FIBROMUSCULAR STROMA anterior PERI-URETHRAL STROMA EJACULATORY DUCTS

CROSS SECTION OF THE PROSTATE FIBROMUSCULAR STROMA anterior PERI-URETHRAL STROMA EJACULATORY DUCTS

TRANZITIONAL ZONE Urethra Seminal Vesicle

TRANZITIONAL ZONE Urethra Seminal Vesicle

CENTRAL ZONE

CENTRAL ZONE

Peripheral Zone

Peripheral Zone

Fibro-muscular Stroma anterior

Fibro-muscular Stroma anterior

HISTOLOGY

HISTOLOGY

Bad Histology

Bad Histology

Peripheral Zone

Peripheral Zone

Central Zone

Central Zone

Central Zone

Central Zone

Central Zone

Central Zone

Central Zone

Central Zone

Central Zone

Central Zone

40 X Seminal Vesicles

40 X Seminal Vesicles

20 X Seminal Vesicles

20 X Seminal Vesicles

20 X Seminal Vesicles

20 X Seminal Vesicles

Paraganglion

Paraganglion

40 X Neurons

40 X Neurons

Benign Lesions

Benign Lesions

Inflammation

Inflammation

Acute Inflammation

Acute Inflammation

Acute Inflammation

Acute Inflammation

Acute Inflammation

Acute Inflammation

Acute Inflammation

Acute Inflammation

Granuloma

Granuloma

20 X Corpora Amylacea

20 X Corpora Amylacea

20 X Corpora Amylacea Calcified

20 X Corpora Amylacea Calcified

200 X Cristalloid

200 X Cristalloid

200 X Stromal Nodules

200 X Stromal Nodules

H Y P E R P L A S I A

H Y P E R P L A S I A

PRIMARY NODULAR HYPERPLASIA

PRIMARY NODULAR HYPERPLASIA

BENIGN NODULAR HYPERPLASIA Usual Patterns Cell Type Special Patterns Mesenchymal Predominantly stromal Mixed Predominantly

BENIGN NODULAR HYPERPLASIA Usual Patterns Cell Type Special Patterns Mesenchymal Predominantly stromal Mixed Predominantly glandular Fibroblast Smooth Muscle Leiomatous Hyperplasia Basal Cells Basal Cell Hyperplasia Secretory Cells Crybiform Hyperplasia Small Cell Hyperplasia

BENIGN NODULAR HYPERPLASIA

BENIGN NODULAR HYPERPLASIA

BENIGN NODULAR HYPERPLASIA

BENIGN NODULAR HYPERPLASIA

BPH & Inflammation

BPH & Inflammation

BPH & Inflammation

BPH & Inflammation

BASAL CELL HYPERPLASIA

BASAL CELL HYPERPLASIA

200 X BASAL CELL HYPERPLASIA

200 X BASAL CELL HYPERPLASIA

200 X BASAL CELL HYPERPLASIA

200 X BASAL CELL HYPERPLASIA

BASAL CELL HYPERPLASIA - HMWCK

BASAL CELL HYPERPLASIA - HMWCK

ATROPHY

ATROPHY

20 X SIMPLE ATROPHY

20 X SIMPLE ATROPHY

200 X ATROPHY

200 X ATROPHY

40 X ATROPHY

40 X ATROPHY

10 X CYSTIC ATROPHY

10 X CYSTIC ATROPHY

PIN Prostatic Intraepithelial Neoplasia

PIN Prostatic Intraepithelial Neoplasia

Prostatic Intraepithelial Neoplasia Mild Secretory cells Carcinoma Dysplasia Lumen Moderate Severe In situ Microinvasive

Prostatic Intraepithelial Neoplasia Mild Secretory cells Carcinoma Dysplasia Lumen Moderate Severe In situ Microinvasive Normal Basal Cells Basal Membrane Low Grade High Grade Prostatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial Neoplasia

Prostatic Intra-epithelial Neoplasia

It continues in Part 2

It continues in Part 2

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