Prospective longterm minimal residual disease monitoring using RQPCR
- Slides: 9
Prospective long-term minimal residual disease monitoring using RQ-PCR in RUNX 1 -RUNX 1 T 1 -positive acute myeloid leukemia: results of the French CBF-2006 trial by Christophe Willekens, Odile Blanchet, Aline Renneville, Pascale Cornillet. Lefebvre, Cécile Pautas, Romain Guieze, Norbert Ifrah, Hervé Dombret, Eric Jourdan, Claude Preudhomme, and Nicolas Boissel haematol Volume 101(3): 328 -335 February 29, 2016 © 2016 by Ferrata Storti Foundation
Patient flow chart. Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation
Peripheral blood (PB) and (BM) bone marrow MRD in 525 paired samples. Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation
Correlation between paired BM and PB MRD transcript ratio at specific time-points. Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation
Characteristics of the 94 patients with CBFA-AML included in the CBF-2006 trial. Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation
Outcome according to PB- or BM-MRD at the end of consolidation therapy (MRD 4). Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation
PB- and BM-MRD in 8 patients with persistent BM-MRD up to two years after end of treatment. Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation
Impact of CMR achievement on patient outcome. Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation
Impact of molecular relapse in patients with complete molecular remission. Christophe Willekens et al. Haematologica 2016; 101: 328335 © 2016 by Ferrata Storti Foundation