Process Intensification Methodologies Applied to LiquidLiquid Systems in

Process Intensification Methodologies Applied to Liquid-Liquid Systems in Structured Equipment An EU Framework 7 NMP project The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP 7/2007 -2013) under grant agreement n° NMP 2 -SL-2008 -214599

Link with other EU NMP projects Project Funding EU F 6 NMP EU FP 7 NMP Value / Duration € 17 m 2005 - 2009 € 5. 5 m 2009 – 2012 € 30 m 2009 – 2013 € 11 m 2011 – 2015 € 11 m EU FP 7 NMP 2009 -2013 € 10 m 2010 - 2014 Objectives Industry-led collaborative research into radical innovation for chemical production technologies New PI methodologies applied to liquid-liquid systems in structured equipment A new paradigm in modular, sustainable production technology validated on seven industrial projects New methodology and novel catalytic systems for chemical production Develop modular production and factory concept using adaptable plants with flexible output Modern polymer-based catalysts and microflow conditions as key element of innovations in fine chemical synthesis

Technical context for project • Two phase liquid-liquid reactions are important chemical processes • Operation and control can be problematic - often batch or semi-batch processing with sub-optimal operation • L-L reactions are often run to the limitations of existing equipment • Drive to develop sustainable and differentiated processes with lower capital and operating costs • Continuous processing using structured equipment (e. g. micro-reactors) has the potential to overcome current limitations • Numerous examples at research level but few compelling examples of processes run at manufacturing scale

Project Overview Project Value € 5. 5 m (€ 3. 5 m EU funding) Duration: 40 months (Jan 2009 – Mar 2012) Objective: Ø Development and validation of a process design methodology for two-phase liquid-liquid reactions, Ø Demonstration in commodity & specialty chemicals. Ø Develop improved understanding of multiphase processes and the design and operation of appropriate micro/meso-structured reactors Partners:

Project participants Partner EU State Role Chemistry Innovation UK Project coordinator FCTUC PT Knowledge provider EPFL CH Knowledge provider WUT PL Knowledge provider IMM D Technology provider Fluidinova PT Technology provider Britest UK Methodology/Industry partnership Givaudan CH End-user Specialty chemicals Huntsman BE End-user Commodity chemicals CUF PT End-user Commodity chemicals

Project structure WP 1: Project coordination meso WP 3: Design of tailored structured devices WP 4 A: Device development and characterization WP 4 B: Final device and plant testing Micro- & milli-structured Reactors Speciality fine chemicals Multipurpose plant Reactor, separator, crystallizer, etc. Netmix®-derived mesostructured reactors Commodity chemicals Experimental Research Facility WP 2: Modelling & Process Description Mathematical modelling and numerical simulations to develop understanding of interaction between subprocesses and equipment structures micro Process scale Device scale micro meso WP 5: Generic knowledge/toolkit Development Develop generic understanding for dev. of processes and equipment WP 6: Training activities. E-learning, demonstrations, website, dissemination events, degree module

Project outputs • Improved fundamental understanding of processes and design requirements • Development and validation of a design methodology & criteria for dealing with two-phase liquid/liquid-reactions • New generation of flexible and high-performance process equipment • Improved sustainability of chemical processes • Dissemination of outputs via: – Mid-term and end of project events – E-learning packages and practical demonstration – Training materials for HEIs – www. fp 7 pills. eu The research leading to these results has received funding from the European Community's Seventh Framework Programme (FP 7/2007 -2013) under grant agreement n° NMP 2 -SL-2008 -214599