Principles of Pharmacology The Pathophysiologic Basis of Drug

Principles of Pharmacology The Pathophysiologic Basis of Drug Therapy Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Chapter 22 Pharmacology of Hemostasis and Thrombosis Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Sequence of Events in Hemostasis • Figure 22 -1 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Platelet Adhesion and Aggregation • Figure 22 -2 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Platelet Activation • Figure 22 -3 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Platelet Activation by Thromboxane A 2 • Figure 22 -4 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Platelet Activation by ADP and Thrombin • Figure 22 -5 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Coagulation Cascade • Figure 22 -6 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Coagulation Factor Activation on Phospholipid Surfaces • Figure 22 -7 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Central Role of Thrombin in the Coagulation Cascade • Figure 22 -8 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Antithrombin III Action • Figure 22 -9 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

The Fibrinolytic System • Figure 22 -10 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Virchow’s Triad • Figure 22 -11 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Overview of Prostaglandin Synthesis • Figure 22 -12 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Mechanism of Action of Antiplatelet Agents • Figure 22 -13 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Mechanism of Action of Warfarin • Figure 22 -14 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins

Differential Effects of Unfractionated Heparin, Low-Molecular. Weight Heparins, Selective Factor Xa Inhibitors, and Direct Thrombin Inhibitors on Coagulation Factor Inactivation • Figure 22 -15 Copyright © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins