Word/Terms List o o o o AFP Benign Carcinoma CEA Leukemia Lymphoma Malignant Metastasis Neoplasm Oncogene Sarcoma Transformation TSTA
Tumor Immunology Benign vs. malignant tumors Types of neoplasms o o o Carcinomas Leukemias/lymphomas Sarcomas
Cell Transformation Characteristics o Nutritional changes o Lack of contact inhibition o Immortality
Chemicals and Cancer o Mitogens o Mutagens o Carcinogens
Genes and Cancer o Oncogenes o Proto-oncogenes
Tumor-specific Transplantation Antigens Origin of TSTAs o o o Point mutations Expressed by germ line cells Expressed by specific cell types Over expressed Post translation changes Viral oncogenes
Oncofetal Antigens o Alpha fetoprotein (AFP) o Carcinoembryonic antigen (CEA)
Tumors of the Immune System o Leukemias n n o ALL AML CLL CML Lymphomas
Tumors and Viruses o Hepatitis B o Human papilloma virus(HPV) o Epstein Barr Virus
Tumors and Evasion of the Immune System o Low immunogenicity o Modulation by antibodies o Tumor secreted suppressors
Immune Response to Tumors o Cells n n n o NK CTLs Macrophages Cytokines n n Interferon TNF
Immunotherapy Against Tumors o ADCC o Toxin conjugation o Radionuclide conjugation