Principles of Immunology Tumor Immunology 42506 WordTerms List

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Principles of Immunology Tumor Immunology 4/25/06

Principles of Immunology Tumor Immunology 4/25/06

Word/Terms List o o o o AFP Benign Carcinoma CEA Leukemia Lymphoma Malignant Metastasis

Word/Terms List o o o o AFP Benign Carcinoma CEA Leukemia Lymphoma Malignant Metastasis Neoplasm Oncogene Sarcoma Transformation TSTA

Tumor Immunology Benign vs. malignant tumors Types of neoplasms o o o Carcinomas Leukemias/lymphomas

Tumor Immunology Benign vs. malignant tumors Types of neoplasms o o o Carcinomas Leukemias/lymphomas Sarcomas

Cell Transformation Characteristics o Nutritional changes o Lack of contact inhibition o Immortality

Cell Transformation Characteristics o Nutritional changes o Lack of contact inhibition o Immortality

Chemicals and Cancer o Mitogens o Mutagens o Carcinogens

Chemicals and Cancer o Mitogens o Mutagens o Carcinogens

Genes and Cancer o Oncogenes o Proto-oncogenes

Genes and Cancer o Oncogenes o Proto-oncogenes

Tumor-specific Transplantation Antigens Origin of TSTAs o o o Point mutations Expressed by germ

Tumor-specific Transplantation Antigens Origin of TSTAs o o o Point mutations Expressed by germ line cells Expressed by specific cell types Over expressed Post translation changes Viral oncogenes

Oncofetal Antigens o Alpha fetoprotein (AFP) o Carcinoembryonic antigen (CEA)

Oncofetal Antigens o Alpha fetoprotein (AFP) o Carcinoembryonic antigen (CEA)

Tumors of the Immune System o Leukemias n n o ALL AML CLL CML

Tumors of the Immune System o Leukemias n n o ALL AML CLL CML Lymphomas

Tumors and Viruses o Hepatitis B o Human papilloma virus(HPV) o Epstein Barr Virus

Tumors and Viruses o Hepatitis B o Human papilloma virus(HPV) o Epstein Barr Virus

Tumors and Evasion of the Immune System o Low immunogenicity o Modulation by antibodies

Tumors and Evasion of the Immune System o Low immunogenicity o Modulation by antibodies o Tumor secreted suppressors

Immune Response to Tumors o Cells n n n o NK CTLs Macrophages Cytokines

Immune Response to Tumors o Cells n n n o NK CTLs Macrophages Cytokines n n Interferon TNF

Immunotherapy Against Tumors o ADCC o Toxin conjugation o Radionuclide conjugation

Immunotherapy Against Tumors o ADCC o Toxin conjugation o Radionuclide conjugation