Prime Astaxanthin Antioxidant Ocular Support Formula Nourish Your

Prime Astaxanthin Antioxidant & Ocular Support Formula Nourish Your Eyes and Yourself CANADA

What is Astaxanthin? o Astaxanthin is a carotenoid responsible for the reddish pigment in: - Salmon - Crab - Krill - Lobster - Algae o o Superior Antioxidant Eye Health Heart Health Skin Health

Member of the Carotenoid Family - Lutein - Astaxanthin isolated and identified from lobster Astacus gammarus in 1938 by Kuhn *G. Britton et al. , Carotenoids Handbook, 2004 -Carotene OH • 732 known carotenoids* • Humans cannot synthesise carotenoids. • Need to obtain carotenoids from food. • Basic carotene structure • Xanthophyll Class Lutein Astaxanthin Molecular Formula: C 40 H 52 O 4 Molecular Weight: 596. 82 CAS No: 472 -61 -7 OH

Astaxanthin’s Skin Benefits • Supports skin health by quenching oxidative stress and inflammation in all skin layers • Promotes healthy skin by improving skin moisture and helping to maintain skin elasticity

Astaxanthin • Cardiovascular Health Benefits: o o Helps maintain normal cholesterol levels by helping to maintain normal serum triglycerides and HDL levels Promotes blood flow to and from the heart, supporting the body’s delivery of nutrients and the removal of waste Helps maintain normal blood pressure Protects LDL (bad cholesterol) from oxidative stress, which promotes healthy arteries

Astaxanthin • Vision Health Benefits: o o o Promotes healthy vision and visual focus Helps reduce occasional eye fatigue Helps prevent oxidative stress in the eye Helps maintain clear vision when using visual electronics (computer eye strain) Supports healthy blood flow in the eye

Eye Fatigue - A Serious Problem

Supports muscle endurance and muscle performance by protecting the skeletal muscle from oxidative stress

Superior Position in Membrane Vitamin C Beta -car oten e

Why Add Astaxanthin to Your Current Health Regimen? • Antioxidant vs. Diet: o o You can eat lots of a food that has a low level of antioxidant activity per gram OR … You can take a concentrated supplement in pill form that has a very high level of antioxidant activity

Why Add Astaxanthin to Your Current Health Regimen? • Antioxidants are best taken in combination vs. alone o o Antioxidants work together and are synergistic 2 or 3 antioxidants have a combined effect greater than the sum of the individual antioxidants. • TIP: Eat a minimum of five to nine servings of fruits and vegetables a day.

Astaxanthin • What Makes Asta. Real Unique? o This product uses only Asta. Real® Astaxanthin, from carefully cultivated microalgae sourced from Gustavsberg, Sweden. o Asta. REAL® is the most studied brand of astaxanthin in the world ‒ ‒ Over 50 Clinical Studies 7 Registered Patents, 3 Patents Pending

® Asta. REAL Astaxanthin Patents No. 6, 245, 818 Muscle and Physical Endurance - increased physical endurance / reduced muscle damage No. 6, 262, 316 Gastric Health - Reduces infection/inflammation of Helicobacter pylori No. 6, 335, 015 Mastitis - Prophylactic treatment for mastitis No. 6, 410, 602 Fertility - Method of increasing the production and improving the quality of semen No. 6, 773, 708 Immune System - Immunomodulation - autoimmune diseases and chronic viral and intracellular bacterial infections No. 6, 923, 967 Dyspeptic Symptoms - Alleviates dyspeptic symptoms No. 7, 078, 040 Anti-Inflammation - Cytokine regulation - inhibiting the expression of inflammatory cytokines and chemokines Patent Pending Eye Fatigue - Reduced eye fatigue / improved visual acuity Patent Pending Cardiovascular – Alleviating vascular failure Patent Pending Diabetic Nephropathy - Gene expression modulator – suppression of development of diabetic nephropathy

Asta. REAL® vs. the Competition • Asta. Real is the highest quality NATURAL astaxanthin available • Supported by patents and studies • Guaranteed for high quality and stability • 6 mg serving vs. the standard 2 -4 mg

Astaxanthin Summary • Who would benefit from Astaxanthin Supplementation? o People who want to recover from exercise. o People wanting to improve skin appearance. o People who want to support eye health. o People who want cardiovascular support. o People with insufficient antioxidants and carotenoids in their diet.

Product Information on PRIME ASTAXANTHIN ANTIOXIDANT & OCULAR SUPPORT FORMULA SCIENCE-BASED | HIGH QUALITY | HIGH POTENCY

Why Prime Astaxanthin is the best! There are many health supplements available, but only Prime Astaxanthin Antioxidant & Ocular Support Formula gives you the highest-grade astaxanthin in its most clinically-studied amounts. It uses purest and most powerful antioxidants available. Asta. Real® uses precision cultivation techniques in state-of the-art facilities, producing only 100 percent natural astaxanthin in a purified, sterile environment. Daily exposure to free radicals—contained within the air we breathe and the food we eat— results in ongoing, long-term physical stress. The widespread oxidative stress they cause to all systems of the body is also believed to be a primary contributor to what we call the aging process. Prime Astaxanthin works against free radicals by providing powerful antioxidant defense to help protect the entire body on a cellular level. The power of Prime Astaxanthin to fight free radicals is of critical importance, but it must also be delivered to the body in sufficient amounts to be truly effective. Typical astaxanthin formulations contain only 2 -4 mg per serving—an amount which falls short in delivering all possible benefits to your body. Prime Astaxanthin Antioxidant & Ocular Support Formula is made exclusively in a 6 mg serving, which is superior for promoting antioxidant for overall health and ocular support. Together, the quantity and the quality delivered by Prime Astaxanthin yields anti-oxidant benefits second to none.

In the News

Primary Benefits • A source of antioxidants • Supports ocular health • Contains 6 mg of natural astaxanthin • Uses Asta. Real® astaxanthin which ensures maximum potency, purity and stability • Asta. REAL® is the most studied brand of astaxanthin in the world with over 50 Clinical Studies

Scientific studies show that Astaxanthin (Asta Real) is important for the following: • Supports cardiovascular health 8, 13, 23, 30 • Helps maintain normal cholesterol levels by helping to maintain normal serum triglycerides and HDL cholesterol levels 8, 9, 12, 13, 31 • Promotes healthy blood flow to and from the heart, supporting the body’s delivery of nutrients and removal of wastes 4, 12 • Helps maintain normal blood pressure 4, 5, 22, 23 • Protects LDL (bad cholesterol) from oxidative stress, which promotes healthy arteries 8, 9, 12, 13, 31 • Promotes healthy vision 10, 14, 15, 16, 17, 19, 20, 21 The aforementioned has not been approved or considered by Health Canada. The aforementioned are findings made in diverse scientific studies regarding Asta. Real®.

Scientific studies show that Astaxanthin (Asta Real) is important for the following: • Helps to prevent oxidative stress in the eye 17, 24 • Helps reduce the occurrence of occasional eye fatigue and eye strain associated with visual electronics 14, 15, 20, 21 • Supports healthy blood flow in the eye, promoting nourishment for the eye and helping to maintain proper eye function 16 • Supports healthy visual focus 14, 15, 20, 21 • Provides powerful antioxidant defense 3, 7, 18 • Promotes healthy skin by improving skin moisture and helping to maintain skin elasticity 24, 28, 29, 30 • Supports muscle endurance and muscle performance by protecting the skeletal muscle from oxidative stress generated by physical activity 6, 11, 26 The aforementioned has not been approved or considered by Health Canada. The aforementioned are findings made in diverse scientific studies regarding Asta. Real®.

Scientific Studies 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) 14) 15) Aoi, W. , et al. Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification. Biochem. Biophys. Res. Com. 366: 892– 897, 2008. Camera, E. , et al. Astaxanthin, canthaxanthin and beta-carotene differently affect UVA-induced oxidative damage and expression of oxidative stress-responsive enzymes. Exp Dermatol. 18(3): 222 -31, 2009. Choi et al. Effects of astaxanthin on oxidative stress in overweight and obese adults. Phytother Research (in-press), 2011. Hussein, G. , et al. Antihypertensive potential and mechanism of action of astaxanthin: II. Vascular reactivity and hemorheology in spontaneously hypertensive rats. Biol Pharm Bull. 28(6): 967 -971, 2005. Hussein, G. , et al. Antihypertensive and neuroprotective effects of astaxanthin in experimental animals. Biol Pharm Bull. 28(1): 47 -52, 2005. Ikeuchi, M. , et al. Effects of astaxanthin supplementation on exercise-induced fatigue in mice. Bio. Pharm. Bull. 29(10): 21062110, 2006. Iwabayashi, et al. Efficacy and safety of eight-week treatment with astaxanthin in individuals screened for increased oxidative stress burden. Journal of Anti-Aging Medicine. 6(4): 15 -21, 2009. Iwamoto, et al. , (2000). Inhibition of low-density lipoprotein oxidation by astaxanthin. Journal of Atherosclerosis Thrombosis. 7(4): 216 -22, 2000. Karppi, et al. Effects of astaxanthin supplementation on lipid peroxidation. Int J Vitam Nutr. Jan; 77 (1): 3 -11, 2007. Kenji, S. , et al. Effect of astaxanthin on accommodation and asthenopia. Efficacy-induced study in healthy volunteers. Journal of Clinical Therapeutics and Medicines. 21(6): 637 -650, 2005. Malmsten, C. and Lignell, A. Dietary supplementation with astaxanthin rich algal meal improves muscle endurance – a double blind study on male students. Carotenoid Science. 13: 20 -22, 2008. Matsuyama, et al. A safety study on the long-term consumption of astaxanthin in healthy human volunteer. Japanese Journal of Complementary and Alternative Medicine. (7): 43 -50, 2010. Miyawaki, et al. Effects of astaxanthin on human blood rheology. Journal of Clinical Therapeutics and Medicines. 21(4): 421429, 2005. Nagaki, Y. , et al. The supplementation effect of Astaxanthin on accommodation and asthenopia. Journal of Clinical Therapeutics and Medicines. 22(1): 41 -54, 2006. Nagaki, Y. , et al. Effects of astaxanthin on accommodation, critical flicker fusion, and pattern visual evoked potential in visual display terminal workers. Journal of Traditional Medicines. 19: 170 -173, 2002.

16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. Scientific Studies Nagaki, Y. , et al. Effects of astaxanthin on retinal capillary blood flow in normal volunteers. Journal of Clinical Therapeutics and Medicines. 21(5): 537 -542, 2005. Naguib, Y. The antioxidant activities of astaxanthin and related carotenoids. Journal of Agricultural and Food Chemistry. 48(4): 11501154, 2000. Nakagawa, et al. Antioxidant effect of astaxanthin on phospholipid peroxidation in human erythrocytes. British Journal of Nutrition. (31): 1 -9, 2011. Nakamura, A. , et al. Changes in visual function following peroral astaxanthin. Japanese Journal of Clinical Ophthalmology. 58(6): 10511054, 2004. Nanako, T. and Masayoshi, K. Effects of astaxanthin on accommodation recovery. Journal of Clinical Therapeutics and Medicines. 21(4): 431 -436, 2005. Nitta, T. , et al. Effects of astaxanthin on accommodation and asthenopia. Dose finding study in healthy volunteers. Journal of Clinical Therapeutics and Medicines. 21(5): 543 -546, 2005. Preuss et al. Astaxanthin lowers blood pressure and lessens the activity of the eroxi-angiotensin system in Zucker Fatty Rats. Journal of Functional Foods. I: 13 -22, 2009. Ruiz, et al. Astaxanthin-enriched-diet reduces blood pressure and improves cardiovascular parameters in spontaneously hypertensive rats. Pharmacological Research. 63(1): 44 -50, 2010. Santocono, M. , et al. Influence of astaxanthin, zeaxanthin, and lutein on DNA damage and repair UVA-irradiated cells. Journal of Photochemistry and Photobiology. 85(3): 205 -215, 2006. Satoh, et al. Preliminary clinical evaluation of toxicity and efficacy of a new astaxanthin-rich Hameotoccus pluvialis. J. Clin. Biochem. Nutr. 44: 280– 284, 2009. Sawaki, K. , et al. Sports performance benefits from taking natural astaxanthin characterized by visual activity and muscle fatigue improvements in humans. J. Clin. Ther. Med. 18(9): 73 -88, 2002. Takahashi N, Kajita M. Effects of astaxanthin on accommodative recovery. J. Clin. Therap. Med. 21(4): 431 -436, 2005. Tominaga, et al. Protective effects of astaxanthin against single oxygen induced damage in human dermal fibroblasts in-vitro. Food Style. 21, 13(1): 84 -86, 2009. Yamashita, et al. Cosmetic benefit of the supplement health food combined astaxanthin and tocotrienol on human skin. Food Style. 21. 6(6): 112 -117, 2002. Yamashita, et al. The Effects of a Dietary Supplement Containing Astaxanthin on Skin Condition. Carotenoid Science. 10: 91 -95, 2006. Yoshida, et al. Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia. Atherosclerosis. 209 (2): 520 -3, 2010. Zhao, et al. Ameliorative effect of astaxanthin on endothelial dysfunction in streptozotocin-induced diabetes in male rats. Arzneimittelforschung. 61(4): 239 -246, 2011.

Product Comparison Chart Prime Astaxanthin Antioxidant & Ocular Support Formula is a first-rate product for promoting antioxidant and ocular support. Prime Astaxanthin Antioxidant & Ocular Support Formula uses Asta. Real® astaxanthin, which ranks among the purest and most powerful antioxidants available. Typical astaxanthin formulations contain only 2 -4 mg per serving - an amount which falls short in delivering all possible benefits for the heart, eyes, skin and muscles. Prime Astaxanthin Antioxidant & Ocular Support Formula delivers a 6 mg serving of high-grade Asta. REAL® astaxanthin, making it superior to its competitors only providing 4 mg. Prime Astaxanthin Antioxidant & Ocular Support Formula is the premier choice due its unequaled ability to combat free radicals at the cellular level.

Product Information PRIME ASTAXANTHIN Code: C 14500 30 Servings UC: $31. 95 (USD) SR: $43. 95 (USD) BV: 23. 5 Gross Profit Per # of Customers Reordering Every 3 Months PRIME ASTAXANTHIN In US Dollars 10 25 50 100 250 500 1000 1500 3000 120 300 600 1200 3000 6000 12000 18, 000 36, 000