PREGNANE X RECEPTOR PXR AND CONSTITUTIVE ANDROSTANE RECEPTOR

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РЕЦЕПТОРИ КСЕНОБІОТИКІВ - PREGNANE X RECEPTOR (PXR) AND CONSTITUTIVE ANDROSTANE RECEPTOR (CAR)

РЕЦЕПТОРИ КСЕНОБІОТИКІВ - PREGNANE X RECEPTOR (PXR) AND CONSTITUTIVE ANDROSTANE RECEPTOR (CAR)

РЕЦЕПТОРИ КСЕНОБІОТИКІВ - PREGNANE X RECEPTOR (PXR) AND CONSTITUTIVE ANDROSTANE RECEPTOR (CAR)

РЕЦЕПТОРИ КСЕНОБІОТИКІВ - PREGNANE X RECEPTOR (PXR) AND CONSTITUTIVE ANDROSTANE RECEPTOR (CAR)

Multidrug Resistance Protein (MDR)

Multidrug Resistance Protein (MDR)

Multidrug Resistance Protein (MDR)

Multidrug Resistance Protein (MDR)

"Albumin is doubtless one of the most important of the animal proximate principles" H.

"Albumin is doubtless one of the most important of the animal proximate principles" H. Ancell (Course of lectures on the physiology and pathology of the blood and other animal fluids. Lancet 1839– 1840)

Історія вивчення регуляції експресії гена альбуміна • Oratz, M. 1970. Oncotic pressure and albumin

Історія вивчення регуляції експресії гена альбуміна • Oratz, M. 1970. Oncotic pressure and albumin synthesis. In Plasma Protein Metabolism, ed. M. A. Rothschild, T. Waldmann, 223 -38. New York: Academic. 560 pp. • Pietrangelo A, Panduro A, Chowdhury JR, Shafritz DA. Albumin gene expression is down-regulated by albumin or macromolecule infusion in the rat // J Clin Invest. 1992 Jun; 89(6): 1755 -60. • Pietrangelo A, Shafritz DA. Homeostatic regulation of hepatocyte nuclear transcription factor 1 expression in cultured hepatoma cells // Proc Natl Acad Sci U S A. 1994 Jan 4; 91(1): 182 -6. • Oka T, Komori N, Kuwahata M, Okada M, Natori Y. Vitamin B 6 modulates expression of albumin gene by inactivating tissue-specific DNA-binding protein in rat liver // Biochem J. 1995 Jul 1; 309 ( Pt 1): 243 -8. • Kang J, Holland M, Jones H, Kaysen GA. Coordinate augmentation in expression of genes encoding transcription factors and liver secretory proteins in hypo-oncotic states // Kidney Int. 1999 Aug; 56(2): 452 -60.

ЯДЕРНІ ФАКТОРИ ГЕПАТОЦИТІВ (Hepatocyte Nuclear Factors, HNFs) – група різних за філогенезом транскрипційних факторів,

ЯДЕРНІ ФАКТОРИ ГЕПАТОЦИТІВ (Hepatocyte Nuclear Factors, HNFs) – група різних за філогенезом транскрипційних факторів, що регулюють експресію більшості генів у гепатоцитах HNF 1 contain a POU-homeodomain and bind to DNA as homodimers HNF 3 contain a winged helix DNA-binding domain and bind to DNA as monomers HNF 4 are nuclear receptors and bind to DNA either as homodimers or RXR heterodimers HNF 6 contain a cut-homeodomain (ONECUT) bind to DNA as monomers

Білок, що регулює обмін стеролів (SREBP, sterol regulatory element binding protein)

Білок, що регулює обмін стеролів (SREBP, sterol regulatory element binding protein)

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