Pregnancy outcomes for neural tube defect NTD affected
Pregnancy outcomes for neural tube defect (NTD) affected pregnancies in different ethnic groups in the UK Jordana Peake If. WH and ICH, UCL (j. peake@ucl. ac. uk)
Overview • • • Background Study Aim Methods Results Conclusions Future work
Neural tube defects (NTDs) Spina bifida Anencephaly Encephalocele • Severe congenital abnormalities caused by failed closure of the embryonic neural tube. • Affect approximately 1 in 1, 000 pregnancies worldwide. • Complex aetiology. • Folic acid recommended for prevention.
Pregnancy outcomes for NTDs
Study Aim To explore how maternal ethnicity influences the decision of whether to continue the pregnancy or not when it is discovered that a baby has an NTD.
Methods Sample All NTD affected pregnancies with known maternal ethnicity in EMSYCAR and SWCAR for the years 2006 to 2011 inclusive • The association between ethnicity and whether the NTD affected pregnancy was terminated or not, was explored using a logistic regression model. • The mitigating effect of whether the NTD was isolated or not; the type of NTD; deprivation; age of mother and age, in weeks, at which the NTD was discovered were also explored.
Results
Results
Results Ethnicity and TOPFA/non-TOPFA model: Pakistani, Black African and Black Caribbean women are less likely to terminate their pregnancy. Deprivation OR for Pakistani and Black African women moves slightly closer to 1; effect for Black Caribbean women no longer significant. Age of discovery No change for ethnicity but effect for deprivation (NTDs are discovered earlier in those less deprived) attenuated Isolated or nonisolated NTD No effect on ethnicity and mild effect on deprivation NTD type No observed effect Age of mother Slightly bigger effect observed for Pakistani mothers i. e. OR moves further from 1 and slight attenuation of effect for deprivation
Results
Conclusions • Pakistani, Black African and Black Caribbean women are less likely than white women to terminate their pregnancy when it is discovered that their baby has an isolated NTD. • A larger sample size is required to elucidate whether the same effect is observed across different NTD types and within the non-isolated NTD group for mothers of Pakistani and Black African ethnic origin.
Future work • Multiple imputation techniques will be used to “fill” missing ethnicity data from Nor. CAS, CAROBB and CARIS • This larger dataset will be used to explore whethere is an ethnic difference for non-isolated cases and any discrepancies across different NTD types. • Reasons why Pakistani women are less likely to terminate their pregnancy are being explored in a qualitative study.
Acknowledgements • EMSYCAR, Nor. CAS, CAROBB, SWCAR and CARIS • Anna Springett at BINOCAR • Professor Andrew Copp, Dr Jill Shawe and Dr Rachel Knowles. • George Kafatos UCL Grand Challenges
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