Practical histopathology Lab 10Handling and Evaluation of lung

ﺑﺴﻢ ﺍﻟﻠﻪ ﺍﻟﺮﺣﻤﻦ ﺍﻟﺮﺣﻴﻢ Practical histopathology Lab 10(Handling and Evaluation of lung biopsies)

Introduction • The lungs are part of our respiratory system along with the trachea, bronchioles, nasal cavity, larynx and the pharynx. • Without our respiratory system our bodies would not be able to breathe oxygen.

Lung structure • The major features of the lungs include the bronchi, the bronchioles, and the alveoli. • The alveoli are the microscopic blood vessel-lined sacks in which oxygen and carbon dioxide are exchanged.

Lungs functions 1. To bring oxygen into the body and exhale waste gases such as carbon dioxide out of the body. As this takes place lungs expand decrease in size. Where does the oxygen go? • The blood cells that circulate through tiny blood vessels near the lungs pick up oxygen and carry it around the body to the sites of respiration. • The oxygen will soon react with glucose to produce energy that our bodies need.

2. Help in the regulation of blood pressure. 3. Balance the p. H of blood. 4. Filter out small blood clot from veins. 5. Influence the concentration of some biologic substances and drugs used in medicine in blood. 6. Provide airflow for the creation of vocal sounds.

Location of your lungs • The base of your lungs rests on the diaphragm. • The diaphragm separates the lungs and heart from the organs in your abdomen. • Lungs are enclosed within your rib cage. • They are protected by the breast bone, back bone as well as the rib cage.

Diseases of the Lung 1. Lung Cancer • It is a disease that disrupts the DNA in the body’s cells. • There are many different causes that can cause lung cancer; smoking, air pollution, and radon gas etc. • There are two types, small cell lung cancer(SCLC) and non-small cell lung cancer(NSCLC). • Staging lung cancer is based on whether the cancer is local or has spread from the lungs to the lymph nodes or other organs.

Non-Small Cell Lung Cancer • It accounts for about 85% of lung cancers and includes: 1. Adenocarcinoma, the most common form of lung cancer in the United States among both men and women. 2. Squamous cell carcinoma, which accounts for 25% of all lung cancers. 3. Large cell carcinoma, which accounts for about 10% of NSCLC tumors.

Stages of non-small cell lung cancer Stage I: The cancer is located only in the lungs and has not spread to any lymph nodes. Stage II: The cancer is in the lung and nearby lymph nodes. Stage III: Cancer is found in the lung and in the lymph nodes in the middle of the chest, also described as locally advanced disease.

Stage IV: This is the most advanced stage of lung cancer, and is also described as advanced disease. This is when the cancer has spread to both lungs, to fluid in the area around the lungs, or to another part of the body, such as the liver or other organs.

Small Cell Lung Cancer • It accounts for the remaining 15% of lung cancers in the United States. • They tend to grow more quickly than NSCLC tumors. • Usually, SCLC is more responsive to chemotherapy than NSCLC.

Stages of Small Cell Lung Cancer • Limited stage: In this stage, cancer is found on one side of the chest, involving just one part of the lung and nearby lymph nodes. • Extensive stage: In this stage, cancer has spread to other regions of the chest or other parts of the body.

Silicosis • It is a respiratory disease caused by inhaling silica dust. • Three types of silicosis exist; simple chronic, accelerated and acute silicosis. • It can be detected by either a chest x-ray, pulmonary function tests purified protein derivative. • The outcome varies on the amount of damage to the lungs.

Silicosis

simple chronic, accelerated and acute silicosis.

Other lung diseases & problems • Asthma – is a chronic, ongoing lung disease linked to acute flare-ups or attacks of difficulty with breathing. • Pneumonia - is a general term for a wide variety of conditions that cause an inflammation of the lungs. • Bronchitis – is an inflammation of the air passages within the lungs. • Pulmonary fibrosis – is hardening or scarring of lung tissue because of excess collagen.

• COPD – is a chronic, ongoing, progressive disease of the lower respiratory tract in the lungs. • Cystic fibrosis – is a chronic, progressive and debilitating disease that affects the lungs, intestines, liver, and pancreas. • Mesothelioma – is a relatively rare cancer, that is usually associated with asbestos. • Tuberculosis – is a bacteria that usually causes disease in the lung.

• Collapsed lung – is a condition where all or part of the lung collapses or deflates due to the space between the lung and the chest cavity becoming filled with air. • Lung abscess – is having pus in the lung. • Respiratory infections – is any infection that occurs to the respiratory system.

How to keep your lungs healthy • Don’t smoke anything. • Maintain a healthy diet. • Try to exercise regularly. • Being immunized can lower your risk of contracting a lung condition. • Use a humidifier to help keep your home as free of irritants and germs as possible.

Thanks for listening & Take care of me. .