PPP Shunt glycogen The pentose phosphate pathway PPP

PPP Shunt glycogen The pentose phosphate pathway (PPP) is the source of ribose (deoxyribose), and NADPH is required for biosynthesis. PPP

Pentose Phosphate Pathway Shunt Synthesize 3 pentose phosphates Ribulose 5 -P Xylulose 5 -P Ribose 5 -P And NADPH (DNA/RNA) (for the reduction of RNA to DNA) Or NADPH and glycolytic intermediates Rapidly dividing cells need lots of NADPH and DNA High PPP activity

The Oxidation Stage of PPP Major reg step Allosteric - NADPH Loss of Carbon

The Non-Oxidation Stage of PPP All equilibruim rxns When cells need lot of NADPH and nucleotides - ribulose 5 -phosphate ribose 5 -phosphate - end of pathway

The Non-Oxidation Stage of PPP Convert 5 C sugars into glycolytic intermediates Can be used in glycolysis of Gluconeogenesis

Pentose Phosphate Pathway Thru PPP 3 Glc-6 -P + 6 NADP+ + 3 H 2 O 2 Fru-6 -P + G 3 P + 6 NADPH + 3 CO 2 Recycle 6 C sugar Allow sub regeneration via PPP and glyconeogenesis 6 ribulose 5 -P Can be metabolized in Glycolysis or Glcneogenesis 6 Glc-6 -P + 12 NADP+ 5 Glc-6 -P + 12 NADPH + 6 CO 2 + Pi 5 Glc 5 -P