PPAR antagonist attenuates mouse immunemediated bone marrow failure

PPARγ antagonist attenuates mouse immune-mediated bone marrow failure by inhibition of T cell function by Kazuya Sato, Xingmin Feng, Jichun Chen, Jungang Li, Pawel Muranski, Marie J. Desierto, Keyvanfar, Daniela Malide, Sachiko Kajigaya, and Neal S. Young haematol Volume 101(1): 57 -67 December 31, 2015 © 2016 by Ferrata Storti Foundation

PPARγ antagonists ameliorate immune-mediated BM failure in AA mice. Kazuya Sato et al. Haematologica 2016; 101: 57 -67 © 2016 by Ferrata Storti Foundation

Alterations of inflammation and adipogenesis by PPARγ antagonists. Kazuya Sato et al. Haematologica 2016; 101: 57 -67 © 2016 by Ferrata Storti Foundation

T cell activation in BADGE-treated AA mice. Kazuya Sato et al. Haematologica 2016; 101: 57 -67 © 2016 by Ferrata Storti Foundation

T cell activation and proliferation are inhibited by BADGE. Dose response of BADGE on CD 25 (A) and CD 150 (B) expression of CD 4+ and CD 8+ T cells. Kazuya Sato et al. Haematologica 2016; 101: 57 -67 © 2016 by Ferrata Storti Foundation

In vivo effect of BADGE on T cells in FVB BM failure model. Kazuya Sato et al. Haematologica 2016; 101: 57 -67 © 2016 by Ferrata Storti Foundation

Marrow and body fat in “fatless” mice with bone marrow failure. Kazuya Sato et al. Haematologica 2016; 101: 57 -67 © 2016 by Ferrata Storti Foundation