POROS Affinity Columns Protein A Protein G and

POROS® Affinity Columns Protein A, Protein G, and Capture. Select® Affinity Columns Intended for analytical scientists supporting the development of biologic drugs. Or for small-scale purification of immunoglobulins, Fabs, or fusion proteins. POROS® Affinity Columns enable: Direct sampling from cell culture or fermentation harvests Precise quantitation of product titers, typically in under 3 minutes with the eluted product being highly purified and suitable for further analysis including mass spectrometry. 1 9/18/2020

POROS® Affinity Columns Prepacked column overview Product Name Specificity Dynamic Binding Capacity (mg/m. L) POROS® A 20 Human, mouse, and 5 other species 19. 0 POROS® G 20 Human, mouse, rat, and 8 other species 9. 0 Human 8. 9 Human, mouse, and rat 4 POROS® Capture. Select® LC Kappa Human, all subclasses 14. 5 POROS® Capture. Select® LC Lambda Human, all subclasses 10 Human 2. 6 POROS® Capture. Select® Ig. G Fc POROS® Capture. Select® Ig. M POROS® Capture. Select® HSA POROS® prepacked columns Column Dimension Column Volume 2. 1 x 30 0. 1 4. 6 x 50 0. 8 4. 6 x 100 1. 7 10 x 100 7. 9 Diameter (mm) x Length (mm) Capture. Select® Columns A collaboration between Life Technologies and BAC 2 (m. L) 9/18/2020

POROS® Affinity Columns Protein A, Protein G, and Capture. Select® specificity Bimolecular type Ig. G 1, Ig. G 2, Ig. G 4 Ig. G 3 Ig. G, CH 2 domain deleted POROS® Protein A & Protein G resins Protein A G Ig. G Fc Kappa Lambda Ig. M Ig. A, Ig. D, Ig. E Fab, Fab'2 Human serum albumin HSA CL Capture. Select® Kappa or Lambda Protein A or Protein G CH 2 CH 3 Capture. Select® Ig. G Fc VL CH 1 Ig. M Albumin fusion protein Ig. G Fc fusion protein VH POROS® Capture. Select® ligands POROS® Protein A, Protein G, and Capture. Select® ligands target multiple Ig. G epitopes. The graphic shows the binding sites for affinity ligands Protein A and Protein G. Novel POROS® Capture. Select® ligands provide alternative specificities that enable rapid binding for the quantitation or purification of engineered immunoglobulins. 3 9/18/2020

POROS® Affinity Columns Additional information Product Bulletin: POROS® Protein A, Protein G, and Capture. Select® Columns Application Note: POROS® A 20 Analytical HPLC Columns Operating Instruction: POROS® Protein A, Protein G and Capture. Select® Affinity Columns Go to BAC: bacbv. com © 2012 Life Technologies Corporation. All rights reserved. The trademarks mentioned herein are the property of Life Technologies Corporation and/or its affiliate(s) or their respective owners. Capture. Select is a registered trademark of BAC BV. 4 9/18/2020