Polycythemia GRACE ORDUNG What is Polycythemia Abnormal increase
Polycythemia GRACE ORDUNG
What is Polycythemia? �Abnormal increase in blood cells Red, white and platelets �Classified as a cancer �Acquired not heredity �Defect in gene JAK 2 V 617 F
Symptoms, Complications and Risk Factors �Itching, headache, dizziness, weakness, sweating, breathing problems, enlarged spleen, numbness, etc. �Stroke, heart problems �Increases with age, men more than women
Normal vs. Polycythemia �Normal �PV �Hb Male: 13. 5 -17. 5 g/d. L Female: 12. 0 -15. 5 g/d. L �Hb Male: > 18. 5 g/d. L Female: > 16. 5 g/d. L WBC: > 12, 000 cells/u. L Platelets: > 400, 000 platelets/ u. L �Hematocrit Male: 38. 8 -50. 0% Female 34. 9 -44. 5 % WBC: 3, 500 -10, 500 cells/u. L Platelets: 150 -450, 000 platelets/u. L
JAK 2 V 617 F Gene �Cause of defect unknown �China Japan Union Hospital, Changchun, China 3935 donors �Copenhagen City Heart Study 10, 507 donors
Treatments �Phlebotomies �Asprinin, hydroxyurea, Interferon A �Antihistamines �Lifestyle changes
References � http: //www. nlm. nih. gov/medlineplus/ency/article/000589. htm � http: //www. ncbi. nlm. nih. gov/pmc/articles/PMC 3046277/ � http: //www. ncbi. nlm. nih. gov/pmc/articles/PMC 1785080/ � http: //www. cancer. gov/cancertopics/types/myeloproliferative � http: //www. mayoclinic. org/diseases-conditions/polycythemia-vera/basics/complications/con� � � 20031013 http: //www. cancer. org/treatmentsandsideeffects/guidetocancerdrugs/hydroxyurea http: //ajcp. ascpjournals. org/content/133/6/942/F 1. expansion. html http: //www. cancer. gov/cancertopics/pdq/treatment/myeloproliferative/Health. Professional/page 3 http: //www. mayoclinic. org/tests-procedures/complete-blood-count/basics/results/prc-20014088 http: //www. nlm. nih. gov/medlineplus/ency/article/003683. htm
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