Please do the following activities on the student

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Please do the following activities on the student media (Chapter 15): - MP 3

Please do the following activities on the student media (Chapter 15): - MP 3 tutor: Chromosomal Basis of Inheritance - Activity: Polyploid Plants (relate to speciation (sympatric)!!) CONCEPT 4: APPLYING THE CHROMOSOMAL BASIS OF INHERITANCE TO ANALYSIS THE EFFECTS OF ALTERATIONS IN CHROMOSOME NUMBER OR STRUCTURE. Campbell: Chapter 15 Holtzclaw: pg 111

But First… Linked Genes from last class… A blue fly with silver spots is

But First… Linked Genes from last class… A blue fly with silver spots is mated with a wild type fly (grey, no spots) and all of the F 1 generation are phenotypically wild (grey, no spots). The F 1 fly is mated with a blue fly with silver spots (test cross) with the following results for the testcross offspring: 1025 wild type 1002 blue with silver spots 352 grey with silver spots 366 blue with no spots Are the genes for blue and silver spots linked? How do you know? If so, what is the recombination frequency for the genes for blue and silver spots?

But First… Linked Genes from last class… 1025 wild type PARENTAL TYPE 1002 blue

But First… Linked Genes from last class… 1025 wild type PARENTAL TYPE 1002 blue with silver spots PARENTAL TYPE 352 grey with silver spots RECOMBINANT 366 blue with no spots RECOMBINANT Are the genes for blue and silver spots linked? YES How do you know? BECAUSE IF IT WAS TRUE INDEPENDENT ASSORTMENT, THE TEST CROSS OF A DOUBLE HETEROZYGOTE AND THE DOUBLE HOMOZYGOUS RECESSIVE WOULD HAVE PRODUCED A 1: 1: 1: 1 RATIO However, the genes are not completely linked… in other words, since some recombinants exist… the chromosomes must have

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But First… Linked Genes from last class… 1025 wild type PARENTAL TYPE 1002 blue

But First… Linked Genes from last class… 1025 wild type PARENTAL TYPE 1002 blue with silver spots PARENTAL TYPE 352 grey with silver spots RECOMBINANT 366 blue with no spots RECOMBINANT If so, what is the recombination frequency for the genes for blue and silver spots? Recombination frequency = #recombinants/total # of offspring = (365+366)/(1025+1002+352+366) = (731)/(2738) = 0. 266 This means that the genes recombine via crossing over 26. 6% of the time!

Try This! Genes A, B, and C are located on the same chromosome. Testcrosses

Try This! Genes A, B, and C are located on the same chromosome. Testcrosses show that the recombination frequency between A and B is 28% and between A and C is 12%. A’s in the middle! Can you determine the linear order of these genes are their relative distance from each other in map units?

Try This! Genes A, B, and C are located on the same chromosome. Testcrosses

Try This! Genes A, B, and C are located on the same chromosome. Testcrosses show that the recombination frequency between A and B is 28% and between A and C is 12%. Can you determine the linear order of these genes are their relative distance from each other in map units? 28 mu 12 mu 40 mu B A C

Learning Intentions Goal: to analyze mechanisms of chromosomal inheritance You must know: q How

Learning Intentions Goal: to analyze mechanisms of chromosomal inheritance You must know: q How the chromosome theory of inheritance connects the physical movement of chromosomes in meiosis to Mendel’s laws of inheritance q How alteration of chromosome number or structurally altered chromosomes can cause genetic disorders

Alteration of Chromosome Number How? Nondisjuction Occurs when homologous chromosomes do not separate properly

Alteration of Chromosome Number How? Nondisjuction Occurs when homologous chromosomes do not separate properly during meiosis II. Result? Aneuploidy Incorrect number of a chromosome Trisomic: three copies of the chromosome Monosomic: one copy of the chromosome OR: Result? Polyploidy More than two complete sets of chromosomes

What happens next? What would the haploid gametes look like?

What happens next? What would the haploid gametes look like?

Down’s Syndrome: aneuploidy

Down’s Syndrome: aneuploidy

 Is this individual trisomic or monosomic?

Is this individual trisomic or monosomic?

Tetraploid Mammal! Polyploidy

Tetraploid Mammal! Polyploidy

Rearrangement of Chromosome Structure Portions of a chromosomes may be lost or rearranged during

Rearrangement of Chromosome Structure Portions of a chromosomes may be lost or rearranged during crossing over Deletion Fragment is lost. Missing genes. Duplication Extra fragment. Extra genes. Inversion Backwards section! May affect genes. Translocation Moving a piece to a nonhomologous chromosome

Translocation

Translocation

Chromosaomal Deletion Example: Cris du Chat Deletion in chromosome 5 in humans Small head,

Chromosaomal Deletion Example: Cris du Chat Deletion in chromosome 5 in humans Small head, unusual facial features, has a cry that sounds like mewing of a distressed cat Death in infancy or early childhood Affects 1 in 20, 000 or 50, 000 of live births

Try This! A spermatocyte produces the following four sperm cells: n+1 n– 1 1)

Try This! A spermatocyte produces the following four sperm cells: n+1 n– 1 1) These cells are the result of which process? 2) When would this happen?

Try This! A spermatocyte produces the following four sperm cells: n+1 1) n+1 n–

Try This! A spermatocyte produces the following four sperm cells: n+1 1) n+1 n– 1 These cells are the result of which process? NONDISJUNCTION 2) n– 1 When would this happen? DURING MEIOSIS I

Learning Intentions Goal: to analyze mechanisms of chromosomal inheritance You must know: ü ü

Learning Intentions Goal: to analyze mechanisms of chromosomal inheritance You must know: ü ü How the chromosome theory of inheritance connects the physical movement of chromosomes in meiosis to Mendel’s laws of inheritance How alteration of chromosome number or structurally altered chromosomes can cause genetic disorders Ø Try Worksheet!