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What are bilateral adrenal pheochromocytomas?
Pheochromocytoma Rule of 10’s • • 10% Found incidentally 10% Familial (MEN 2 A, MEN 2 B) 10% Extra-adrenal 10% Bilateral (multiple) 10% Calcify 10% Children 10% Recurrence 10% Malignant
Multiple Endocrine Neoplasia 2 (MEN 2) • MEN 2 A o o o • Medullary thyroid cancer Pheochromocytoma Parathyroid adenoma MEN 2 B o o Medullary thyroid cancer Pheochromocytoma Mucosal neuromas (lips and tongue) Marfanoid habitus
Pheochromocytoma • • Rare but fatal catecholamines producing tumor Incidence: 2 -8/million people/year Account for 4% of adrenal incidentaloma Rule of 10’s: o • 10% bilateral, 10% extra-adrenal, 10% familial, 10% malignant Aside from catecholamines, it can also secrete dopamine, ACTH, PTH, calcitonin, vaso-intestinal polypeptide
Pheochromocytoma • • Rare but fatal catecholamines producing tumor Incidence: 2 -8/million people/year Account for 4% of adrenal incidentaloma Rule of 10’s: o • 10% bilateral, 10% extra-adrenal, 10% familial, 10% malignant Aside from catecholamines, it can also secrete dopamine, ACTH, PTH, calcitonin, vaso-intestinal polypeptide
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