Pharmacokinetics of Fenbendazole Suspension and Amoxicillin Suspension Michelle

Pharmacokinetics of Fenbendazole Suspension and Amoxicillin Suspension Michelle Hervey Pharmacology and Pharmacy VETE 4305 02/01/2015

Patient History & Condition Treated Scrappy is a 6 year old, N/M, Australian Shepherd who has presented to the clinic with hematochezia for the passed couple of days. The patient is eating, and drinking normally. Upon fecal floatation Trichuris vulpis was for identified on the slide. http: //www. haustierratgeber. de/hunde/ras sen/australian-shepherd/ http: //server. ugent. be/groups/parasites pics/wiki/3 debb/Trichuris_vulpis. html

Medications Used for Treatment of Trichuris vulpis and Secondary Infection Fenbendazole Suspension http: //www. msd-animalhealth. co. uk/products_public/panacur_10 __liquid/overview. aspx Amoxacillin Suspension http: //store. mcguff. com/products/38 55. aspx

Metabolism of Fenbendazole Suspension This drug is only marginally absorbed after administered orally (Plumb 2011). • Amount absorbed in the gut depends on the solubility of the drug, not the dose given (Plumb 2011). • Bioavailability is increased if drug is given with food (Plumb 2011). • Fat in foods does not alter bioavailability of the drug much (Plumb 2011). • • Fenbendazole is a methylcarbonate benzimidazole antiparasitic and has a broad spectrum of activity against pathogenic parasites (Plumb 2011). Mechanism of action is said to be the disruption of intracellular microtubular transport systems binding selectively and damaging tubulin, preventing tubulin polymerization, and inhibiting microtubular formation (Plumb 2011). � Acts at a higher concentrations to interfere with metabolic pathways within helminths, and inhibit metabolic enzymes (Plumb 2011). � Time dependent antiparasitic agent (Plumb 2011). •

Elimination of Fenbendazole �Fenbendazole is excreted from the intestinal tract. �It is known for it’s ability to kill intestinal parasites slowly.

Metabolism of Amoxicillin Suspension �Time-dependent, bactericidal agent that inhibits cell wall synthesis (Plumb 2011). �Is absorbed better orally. �Relatively stable in gastric acid. �Food will decrease the rate of absorption, but not the extent of oral absorption. �The drug is distributed to tissues, liver, lungs, muscle, bile, ascitic, pleural and synovial fluids.

Elimination of Amoxicillin Suspension �Eliminated through the kidneys through tubular secretion. �Some of the drug can be eliminated in the urine.

Agonist or Antagonist Fenbendazole Suspension Amoxicillin Suspension � This drug is known as an agonist � This drug is known to be an because it binds to tubulin and damages it. � This prevents tubulin polymerization and inhibits microtubule formation (Plumb 2011). antagonist , beta-lactam antibiotics bind to enzymes within cytoplasmic membrane that involve cell wall synthesis (Plumb 2011). � The drug inhibits or blocks cell wall synthesis of actively growing bacteria (Plumb 2011).

Conclusion Scrappy is given: �Fenbendazole for 3 consecutive days SID for treatment of Trichuris vulpis. �Amoxicillin for 10 days BID for secondary infection due to the intestinal parasite Trichuris vulpis. �Scrappy will return in two weeks to recheck fecal floatation to make sure he is free of intestinal parasites.

References Plumb, Donald C. , (2011). Plumb’s Veterinary Drug Handbook 7 th Edition, Pharm Vet Inc. Romich, Janet A. , (2010). Fundamentals of Pharmacology for Veterinary Technicians Second Edition. Delmar