PharmaceuticsI CHAPTER 2 INTRODUCTION TO PHARMACOPOEIAS Mr Biradar

Pharmaceutics-I CHAPTER 2 INTRODUCTION TO PHARMACOPOEIAS Mr. Biradar M. M https: //smartpharmacystudy. wordpress. com

Introduction � Pharmacopoeia Pharmakon means “a drug” and poein means “to make”. Definition - Pharmacopoeia is defined as a compressive book which is issued under the authority of government and contains a list of drug and formulae used for medicinal preparation with description and the tests for those substances and the standards to which they must confirm. � Example: I. P. , B. P. , USP, European Pharmacopoeia, etc. • Why they are needed? Pharmacopoeias are necessary because it gives complete information about the drugs, such as its molecular weight, formula, identification test, standards, assay, preparations etc https: //smartpharmacystudy. wordpress. com

History of Indian Pharmacopoeia � The government of India directed the Drugs Technical Advisory Board Ø to list the drugs that are used in India, which are not mentioned in British Pharmacopoeia. Ø and also recommend the standards to be prescribed to maintain uniformity and the chemical tests to be used to establish identity and purity. � The Government of India published the Indian Pharmacopoeal List in 1946 as a supplement to British Pharmacopoeia. The term list in the title was ‘misleading’ in that, the book not only contained a list of drugs which were of substantial medicinal value but also laid down standards. � The Indian Pharmacopoeial List contained about 180 monographs and a number of appendices prepared on the lines of the British Pharmacopoeia. Approximately 100 monographs were on vegetable drugs growing in India and on their galenicals. https: //smartpharmacystudy. wordpress. com

History of Indian Pharmacopoeia � The Pharmaceuticals and Drugs Research Committee of the Council of Scientific and Industrial Research decided in February 1947 to compile a ’Brochure’ to highlight the information and clinical users of the important indigenous drugs of India. Later on it was decided to prepare a ’Codex’ instead of Brochure on the lines of the British Pharmaceutical Codex. � The first Indian Pharmaceutical Codex published in 1953. The Codex consisted of two parts. The part carried about 190 general monographs on natural product and drugs of vegetable and animal origin, and a few chemicals. The second part consisted of formulary of galenicals and other preparations. � After the publications of the Indian Pharmacopoeial List the Government of India, constituted an eleven member Indian Pharmacopoeial Committee in 1948, in their notification No. F. 11/48 -DS dated 23 rd November, 1948, for preparing the Pharmacopoeia of India. � The first edition of Pharmacopoeia of India was compiled and then published in 1955. https: //smartpharmacystudy. wordpress. com

Editions of Pharmacopoeia of India 1. First Edition in 1955 2. Second Edition in 1966 3. Third Edition in 1985 4. Fourth Edition in 1996 5. Fifth Edition in 2007 6. Sixth Edition in 2010 7. Seventh Edition 2014 https: //smartpharmacystudy. wordpress. com

Salient Features of Third Edition of IP 1985 � New analytical techniques such as flame photometry, Flurometry, have been introduced as official method for certain chemical analysis. � Dissolution test has introduced in the case of certain tablets. � Disintegration Test has been amended by modifying the design of apparatus and method of testing. � A microbial limit test has been prescribed for certain pharmaceutical aid & oral liquid preparation. � Pyrogen test has been revised to make the test less time consuming than the previous method. � Gas liquid chromatography has been recognized as an alternative method for the determination of alcohol concentration in various preparations. https: //smartpharmacystudy. wordpress. com

Salient Features of Third Edition of IP 1985 � Test for determination of viscosity has been modified by introduction to other method involves. � The new appendix on water for pharmaceutical use” has been introduced to clearly indicate the different official standard in respect of purified water. � Some of the drugs have been renamed in this edition. � Many drugs have been omitted from the third edition and many new drugs have been included in the third edition. � It provides the official standard to the new drug which came into use after the publication of first addendum to third edition. https: //smartpharmacystudy. wordpress. com

Salient Features of Fourth Edition of IP 1996 � It contain 1149 monographs and 123 appendices and available in Two volumes. � Computer generated structural formulas. � Titles changed to common e. g. Hyoscine Hydrobromide for scopolamine hydrobromide. � Infra-red and UV Spectrophotometric test added alternative to chemical test. � HPLC used for analysis e. g bioassay of insulin replaced with HPLC. � Test for bacterial endotoxin substitute to pyrogen test introduced. A number of general monographs have included. � Quantitative test for determination of particulate matter in injectable replaced by quantitative test of previous edition. � Bioassay provided for vaccine. � ORS-Citrate formula recommended by WHO introduced https: //smartpharmacystudy. wordpress. com

Important Questions �Define Pharmacopoeia. List any four books. Or Give example. Or List India pharmacopoeia �(In which year the various editions of pharmacopoeia of India came out? ) �Why Pharmacopoeia is needed? �Write the history of Indian pharmacopoeia. �Write the salient features of third edition of Indian pharmacopoeia. �Write the salient features of fourth edition of I. P. https: //smartpharmacystudy. wordpress. com

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