PET Center Scanner Chemistry research Cyclotron Synthesis Module

PET Center 동위원소합성실 Scanner Chemistry research

동위원소 합성실 Cyclotron Synthesis Module Q. C

사이클로트론의 작동원리 : Ion Source Injection System

RF(Radio Frequency) System + + + - + + DC Acceleration - + - AC Acceleration

RF System의 구성 및 Procedure Frequecy Synthesize RF Control Box RF Driver RF Amplifier Transmission line Resonator

사이클로트론에서 생산되는 방사성핵종의 핵반응과 특징 방사성 핵종 핵반응 표적 반감기(분) 화학적 형태 13 N 16 O(p, α)13 N H 2 O(Liquid) 10 [13 N]NO 2 -/NO 3 - 11 C 14 N(p, α)11 C N 2(Gas) 20 [11 C]CO 2 15 O 15 N(p, n)15 O N 2/O 2(Gas) 18 F 18 O(p, n)18 F H 218 O(Liquid) 2 [15 O]O 2 110 [18 F]F-

18 F-FDG 합성 + K - KCO 3 M+ 18 F- KCO CO 3 - KCO 3 + + - N R 3 KCO CO 3 N+R 3 KCO CO 3 - 18 - + 18 - N R 3 F - N+R 3 KCO 3 - + N R 3 KCO CO 3 + - N R 3 KCO CO 3 + + + - N R 3 KCO 3 N+R 3 KCO CO 3 - + N R 3 KCO CO 3 - N R 3 KCO CO 3 + CO 3 K KCO - M KCO 3 K + 18 - F K + KCO 3 -

OA c Ac. O OA c K 2 CO 3 18 K 2, 2, 2 , F OT f O OA c O Ac. O A CN, D OA c 18 F OH HCl(aq) O HO HO D OH 18 - F 2 -[18 F]Fluoro-2 -deoxyglucose O O OAc = O OT f CH 3 = O S O CF 3

11 C-Methionine 합성

동위원소합성실에서 필요한 장비들 • Hot cell wall thickness: 〉5 cm dose calibrator, vacuum, ventilation, glow light, UV light, 110 V, 220 V • Dose Calibrator • Clean bench • TLC • HPLC • Dry oven

동위원소합성실에서 필요한 장비들 • • • Water Bath Survey meter Voltex mixer GC L-block Syringe carrying shield 3차 D. W MCA Ultrasonic bath p. H meter Electric balance Laminar airflow hood