PCORI Research Priorities and Relevant Examples Anne Trontell

PCORI Research Priorities and Relevant Examples Anne Trontell, MD, MPH Associate Director, Clinical Effectiveness and Decision Sciences Patient-Centered Outcomes Research Institute Women’s Health Technologies CRN Annual Meeting FDA White Oak Campus in Silver Spring September 7, 2018 1

Conflicts of Interest/Disclaimer • No conflicts to disclose • Statements and opinions are mine alone and should not be attributed as the opinions, practices, or policies of the Patient Centered Outcomes Research Institute 2

PCORI’s Approach to Research • An independent, non-profit research institute supporting comparative effectiveness research to address multi-stakeholder questions about health care choices • Focus on patient-centered outcomes in comparing the clinical effectiveness of 2 or more options to care for a clinical condition or to improve health care delivery • Research done in real-world populations and settings with attention to subgroup differences • Engagement of patients and other stakeholders throughout the research process • National Research Priorities established with input from PCORI Board of Governors & Methodology committee, as well as patients, other stakeholders, and open public comments

PCORI National Priorities for Research Assessment of Prevention, Diagnosis, and Treatment Options Research that: • Compares the effectiveness and safety of alternative prevention, diagnosis, and treatment options • Determines which options work best overall and for different subgroups of patients 4

PCORI National Priorities for Research Assessment of Prevention, Diagnosis, and Treatment Options Improving Healthcare Systems Research that: • Compares a variety of health system-level approaches to optimize the quality, outcomes, and efficiency of patient care • System levels include patients, families, providers, care teams, organizations, practice settings, delivery options, or policies • Examples: Innovative use of health information technology, care coordination for complex conditions, and effective workforce deployment 5

PCORI National Priorities for Research Assessment of Prevention, Diagnosis, and Treatment Options Improving Healthcare Systems Communication and Dissemination Research on: • Effective ways to provider information produced by CER • Empowering people to ask for and use the information • Supporting shared decision making between patients and their providers 6

PCORI National Priorities for Research Assessment of Prevention, Diagnosis, and Treatment Options Improving Healthcare Systems Communication and Dissemination Research Addressing Disparities Research on: • Reduction or elimination of disparities in health or health care • Prevention, diagnosis, or treatment effectiveness AND health care system interventions to reduce barriers or identify best practices • Healthcare required to achieve best outcomes in each population 7

PCORI National Priorities for Research Assessment of Prevention, Diagnosis, and Treatment Options Improving Healthcare Systems Communication and Dissemination Research Addressing Disparities Research on: • Building data infrastructure (PCORnet) • Determining best methods of current approaches such as registries • Improving analytic methods • Training researchers, patients, and other stakeholders in how to participate in comparative effectiveness research Accelerating Patient-Centered Outcomes Research and Methodological Research 8

PCORI Research Investments 9

Questions Anne Trontell, MD, MPH www. pcori. org info@pcori. org