Pathophysiology Zhao Mingyao Jasper Department of Pathophysiology Medical

Pathophysiology Zhao Mingyao (Jasper) Department of Pathophysiology Medical College, Zhengzhou University zmy 66@zzu. edu. cn/67739263(o)

Top 10 China’s Universities for MBBS study with moderate tuition fees (Duration: 6 years, 2012 ) University Tuition fee RMB( USD) per year 1. Central South University 32000 (5160) 6. Jiangsu University 22000 (3500) 2. Zhengzhou University***** 26000 (4195) 7. Dalian Medical University 42000 (6774) 3. Southeast University 30000 (4840) 8. Wuhan University 32000 (5160) 4. Huazhong University of Science and Technology 40000 (6452) 9. Capital Medical University 35000 (5500) 5. Tianjin Medical University 41000 (6620) 10. Xi’an Jiaotong University 40000 (6600) ***** 16/72 (22. 2%)

A true doctor Consist of every day and every class about 5 , 10, 20 y later ? In ZZU now Study hard for good future could not find a position in society

2012 -031 -28 How many attend class? Total 72.

Data analyse • 16/72 (22. 2%) international students from ZZU passed Medical License Exams in India , 2012 46 failed • In India, More than 6000 students from the world participated in the Medical License Exams in 2011，800 passed it. 60 graduates from TMU attended the exams and 39 of them passed(65%). • Among 800 passman, Mr. Aurabh Suman came second in the exams.

Roll No 11275357 Name GAURAV JOSHI Course FMGE Result PASS Session SEPTEMER 2011 Date Of Birth 30/07/88 Marks Obtained : 182 (Maximum Marks : 300) The above displayed results are for internet based information only. Result letters are sent to all candidates by post. Candidates may verify their results from signed copy of result placed at the reception office of the National Board of examinations, Ansari Nagar, New Delhi. Home | About Us | RTI | Tenders| FAQ’s| DNB Vacancy|Application Status| Contact Us | Disclaimer | Sitemap

Run fast to get worm Run fast to get gold medal You pass Medical License Exams as soon as possible, can get ideal job earlier

How to do? I only hear; I forget I see, write down and repeat; I remember I do and think; I understand

Preface to Pathophysiology 1. 2. 3. 4. What is Pathophysiology ？ Why to study it？ How to study it？ What is it consisted of in our textbook?

1. What is pathophysiology?

Pathophysiology ? = • Clinical Physiology • Medical Physiology • Physiology of Disease • Physiology of Disordered Function

Pathophysiology ? = abnormal physiology + abnormal biochemistry

Pathophysiology = Explore the rule of origin and evolution of disease processes (the underlying mechanisms). Basing on physiology and biochemistry

The Methodologies Used in Pathophysiology n. Experiments study n. Clinical observation n. Epidemiological study

2. Why to study Pathophysiology ？ ? Basic medicine Clinical medicine explain “Why and How” of diseases

Why Is Pathophysiology Important? n An essential introduction to clinical medicine n A bridge: basic medicine and diseases n n n Enables us to understand why and how diseases develop Various clinical manifestations appear, which are the underlying mechanisms In so doing devise rational therapeutics

3. How to study pathophysiology？ Success comes with industry, but diligence …?

Major Points in Learning Pathophysiology The general concepts n The etiology and pathogenesis n The alterations of metabolism and function n The principles for prevention and therapies n

4. Content of pathophysiology in this textbook General introduction on disease Pathological process Systemic and organic ~ Cellular and molecular ~

Chapter 1 Conspectus of Disease

1. Concept of Disease n n Aberrant manifestation of deregulated homeostasis caused by harmful agents The development of a disease is a pathologic process with a characteristic set of signs and symptoms involved in the whole body or any of its parts

Concept of Health Without any evidence of disease, and a state of complete well-being physically, socially and psychologically -----WHO health subhealth transition stage disease

2. Etiology of Disease n Study the causative agents n Answer the question why disease happens

complete well-being physically socially psychologically Extrinsic Factors Intrinsic Factors Predisposing factors Precipitating factors

3. Pathogenesis of diseases

General rules for pathogenesis of diseases (1) (2) (3) (4) Disruption of homeostasis Process of damage and anti-damage Reversal role of cause and result Correlation between systemic and local regulations furuncle

Radiation Trauma Microbe Monocyte Detoxification Carcinogen Physic barrier Coagulation Stress Teratologic Eyewinker Inflammation Immunoreaction Pyrogen Stressor Process of damage and anti-damage

Basic Mechanisms for Disease u Neural regulations u Humoral regulations u Cellular regulations u Molecular regulations

4. Phases of Diseases 高潮 序曲 前奏 尾声 Clinic symptoms Disease Prodrome Latency Recovery

Outcome of Disease Recovery Complete recovery Incomplete recovery Death

Death u The body as a whole stops working forever u Brain death is the marker for the diagnosis

Brain Death (WHO criteria) • • • Cessation of spontaneous respiration Irreversible coma Absence of cephalic reflexes Dilated or fixed pupils Absence of any electrical activity of the brain • Absence of brain blood flow

Significance for diagnosis of brain death p In favor of recording the time of death p Define the time to terminate for the rescue p In favor of organ transplantation

How to do? • I only hear; I forget • I see, write down and repeat; I remember • I do and think; I understand

Thank you!