Path to My CAREER Goal for NSF CAREER

Path to My CAREER Goal - for NSF CAREER Proposal Writing Workshop Xingwei (Vivian) Wang, Ph. D. Assistant Professor Department of Electrical and Computer Engineering University of Massachusetts Lowell Phone: (978) 934 -1981 Xingwei_Wang@uml. edu http: //faculty. uml. edu/xwang

NSF CAREER Proposal • What is an NSF CAREER proposal? • Is it the same as the regular NSF proposals?

NSF CAREER Proposal • A roadmap

NSF CAREER Proposal • • A roadmap Where am I now? Where do I want to go? Which path to take?

NSF CAREER Proposal • A roadmap • Who am I and where am I now? • What is my long-term CAREER goal? • How to reach my goal?

My Long Term CARER Goal • Become a leader in the optical sensing area.

Who Am I? • Education – M. S. , Ph. D. , Electrical and Computer Engineering Virginia Tech. – Certificate, Future Professoriate, Virginia Tech. – B. S. , Electrical and Computer Engineering, Zhongshan University, Guangzhou, China. • Training – Combination of expertise in electrical engineering, optics, and sensor technology. 7

Research Activities in VT • Biosensors – “an oligonucleotide functionalized fiber probe with a miniature protrusion for label-free DNA sequence detection” – won Paul E. Torgerson Research Excellence Award (2006) from Virginia Tech (VT). • Sensors for harsh environment applications – successfully verified near the fan of a turbine engine – 6 VT invention disclosures; 1 licensed to a company (Prime Photonics) for commercialization.

Research Activities in UML • Biosensors – Massachusetts Life Science Center (MLSC) New Investigator Research Award • Optical fiber tip blood pressure sensor – Sponsored by UMass Commercial Ventures and Intellectual Property (CVIP) – 1 provisional patent • Optical temperature sensor – an NSF collaborative grant • Miniature optical acoustic sensors using MEMS technology – Sponsored by Army Research Lab (ARL) – 1 US patent

Blood Pressure Sensor • Initial market thrust: angioplasty $8 billion/year. Photo of the a blood pressure sensor inserted in a guidewire. • Broad applications: pressure measurements in lung, brain, intestines and other areas. • PCT International Application for filling in the US receiving office, Application No. PCT/US 10/40460 (29 June 2010) Comparison with current pressure sensor UML Sensor Pressure. Wire® (St. Jude Medical)** Optical Electrical Immune to EMI Susceptible to EMI Biocompatible material Electrical wires inside the patient body ~ $50 ~ $600 ** http: //www. radi. se/home. aspx? n=8&m=6&s=8&r=1 The pressure sensor in the left anterior descending coronary artery

Blood Pressure Sensor Fractional flow reserve (FFR) Pressure decreased from 50 mm. Hg to 45 mm. Hg, caused by complete occlusion of coronary vessel Plaque: Pa/Pd = 0. 7 No plaque: Pa/Pd = 1 Blast event measurement (Fast response) Blast wave response comparison. The rise time of our sensor is 0. 4 μs. The reference sensor is 12 μs. Rise time of our sensor is 0. 4 μs Rise time of the reference sensor is 12 μs

Relationship between CAREER goal and prior funding support? CAREER topic?

CAREER Proposal Topic Principle Novel Mechanism for Generation and Receiving of Ultrasound on a Single Fiber Using Nanoparticles. The ultrasonic wave is steered by the phased array technique. Application and Marketing Comparison with current ultrasonic transducer Miniature Size? Safety to patients for in-vivo applications? Coronary intravascular ultrasound (IVUS) for coronary artery disease diagnosis Work in strong electromagnetic environments? High Temperature Survivability? Higher frequency? Optical 125 µm diameter Yes. Biocompatible material. Electrical Millimeter size Depends on packaging. Electrical wires inside the patient body. Yes. Immune to EMI. No. Susceptible to EMI Up to 600 ºC No. >30 MHz <10 MHz

Intellectual Merits • 1) This proposal will be the first attempt to explore nanoparticles for photoacoustic generation in an ultrasound probe, which is expected to enhance the ultrasound generation efficiency. • 2) The outcome of this research will open up a new avenue for research on integration of ultrasound generation and receiving on a single optical fiber tip. • 3) The research will be the first attempt to optically steer the direction of ultrasound generated in an optical fiber which could allow fast 360 -degree cross section view and defect detection in any angle.

Relationship between CAREER goal and prior funding support

Where Am I Now? • Grants: – NSF CAREER Award; $400 K – Massachusetts Life Sciences Center New Investigator Matching Grant, $ 599, 775. – NSF MRI ($1. 15 M); PI – NSF MRI ($507, 980); co-PI – NSF collaborative grant; PI in UML (not lead) – Companies (Raytheon; Vaso. Tech; etc. ) • Group: – 1 Postdoctoral Researcher; 7 Ph. D. candidates (1 Ph. D. student graduated); 1 M. S. student; 3 REU students

Think about… • Where you are now? • Where do you want to go? • Which path to take?

Listen • Listen to Dr. ZJ Pei • Read “NSF CAREER Proposal Writing Tips”, ZJ. Pei, http: //www. lulu. com/product/paperback/nsfcareer-proposal-writing-tips/703013 • Attend NSF CAREER Proposal Writing Workshop; CMMI grantee conference

Prepare Well • Prepare well (preliminary results; educational plans; collaboration letters; etc. ) • Listen to advice/suggestions (mentors; peers; students) • Revise and revise

Enjoy the Journey to the CAREER Goal • Manage time efficiently • Get excited about research • Collaborate

Acknowledgement • • • Profs. Pei and Gao; UConn NSF UML colleagues My group members