Paracetamol for low back pain Saragiotto et al

Paracetamol for low back pain Saragiotto et al (2016) Trusted evidence. Informed decisions. Better health. This document is licensed under a Creative Commons Attribution Non. Commercial. No. Derivatives 4. 0 International License: http: //creativecommons. org/licenses/by-nc-nd/4. 0/ That means this document can be used and shared as long as IWH is credited as the source, the contents are not modified, and the contents are used for non-commercial purposes. If you wish to modify and/or use the contents for commercial purposes, please contact ip@iwh. on. ca.

Paracetamol for low back pain Saragiotto et al (2016) Overview of the study Objectives: • To investigate the efficacy and safety of paracetamol for non-specific LBP Methods: • Evidence current up to 7 August 2015 • Participants: People with acute, subacute or chronic non-specific LBP • Intervention: Any dosing regime of paracetamol • Outcomes: o Primary: Pain and disability o Secondary: Quality of life, function, adverse effects, global impression of recovery, sleep quality, patients adherence, use of rescue medication

Paracetamol for low back pain Saragiotto et al (2016) Results & Conclusions • 3 trials (1825 participants) Intervention Paracetamol Evidence Quality of evidence No differences compared to placebo in terms of pain and disability for acute LBP at both immediate and short-term High No effect on physical and mental components of quality of life at 4 weeks and unclear effect at 12 weeks High No better than placebo for function High No effects on pain in chronic LBP Very low Ø Adverse events: No differences across groups for adverse events Ø Paracetamol does not produce better outcomes than placebo for people with acute LBP, and it’s uncertain if it has any effect on chronic LBP