PAOG nascholing Jeugdgez Maastricht 25 Januar Tomris Cesuroglu
- Slides: 21
PAOG nascholing Jeugdgez Maastricht, 25 Januar Tomris Cesuroglu, MD Institute for Public Health Genomics
Research into Child Health in Europe RICHE http: //childhealthresearch. eu
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Perspectives in Personalized Health Care Tomris Cesuroglu, MD Institute for Public Health Genomics PAOG nascholing Jeugdgezondheidszorg Maastricht, 25 January 2011
1% of burden of disease 22% of burden of disease 77% of burden of disease Disease ____________________ threshold Life style External factors Genetic structure Genetic diseases External factors *Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research Complex diseases
An Example to a Single Nucleotide Polymorphism (SNP) Start Codon Stop Codon ┐└ TAT ATA TCG AGC TAC ATG GGC CCG TAC ATG ATA TAT CGT GCA ACC TGG GTA CAT AAT TTA TCG AGC ATT TAA CGA GCT TGA ACT ┐└
An Example to a Single Nucleotide Polymorphism (SNP) Start Codon Stop Codon ┐└ TAT ATA TCG AGC TAC ATG GGC CCG TAC ATG ATA TAT CGT GCA GCC CGG GTA CAT AAT TTA TCG AGC ATT TAA CGA GCT TGA ACT ┐└
Gene and Environment/Life Style Interaction Genetic Polymorphism Dark skin Fair skin Which one is better? *Slide series used with the courtesy of GENAR Institute for Public Health and Genomics Research
Genetic variation: Is it good or bad? Fair skin Norway Nigeria Dark skin Happily living in Fjords Happily living under African sun
Genetic variation: Is it good or bad? Fair skin Norway Nigeria Dark skin
Genetic variation: Is it good or bad? Fair skin Norway Nigeria • Gets red • Burns • Melanoma develops Dark skin
Genetic variation: Is it good or bad? Fair skin • Not enough sunshine • Vitamin D deficiency • Develops osteoporosis Norway Nigeria Dark skin • Gets red • Burns • Melanoma develops
Genetic variation: Is it good or bad? Fair skin • Not enough sunshine • Vitamin D deficiency • Develops osteoporosis Norway Nigeria Dark skin Positive intervention: Protecion from the sun
Genetic variation: Is it good or bad? Fair skin Positive intervention: Vitamin D supplements Norway Nigeria Dark skin Positive intervention: Protecion from the sun
Eric Assamoa Transcription (m. RNA production) Translation in ribosom (synthesis of amino acid chain) Protein GSTP 1 Effective detoxification GSTP 1 (A 313 G Homozygous) Protein Ineffective detoxification
Disease Threshold Early Symptoms Threshold Check-Up Early Diagnosis and Treatment Death Conception Life Style and Environmental Conditions Genetic Predisposition Pathology Development Phase I *Slide used with the courtesy of GENAR Institute for Public Health and Genomics Research Early Disease Symp. Phase III Phase II
Thank you for your attention! Tomris Cesuroglu, MD t. cesuroglu@maastrichtuniversity. nl
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