Pancreas Pancreatic juice 1 to 1 5 L

Pancreas

Pancreatic juice � 1 to 1. 5 L / day � Exocrine portion � Colorless, odorless, highly alkaline fluid of low viscosity Alkaline because of HCO 3 - � p. H : 8 to 8. 4 �

Composition of Pancreatic juice: � � 99% H 2 O 1 % solids Inorganic : � � Cations : Na+, K+, Mg++, Ca++ Anions : HCO 3 -, Cl-, SO 4 --, HPO 4—

Organic: � � � Immunoglobulin's Albumins Kallikreins Enzymes Mucus

Enzymes Proteolytic � Trypsinogen � Chymotrypsinogen � Procarboxypeptidase A � Procarboxypeptidase B � Proelastase. � Collagen.

Amylolytic Pancreatic amylase. Lipolytic Pancreatic lipase. Phospholipase. Nucleases: RNAase DNAase. Trypsin inhibitor

Endocrine E x o c r i n e

Regulation of Pancreatic secretion: 3 Phases Cephalic (Vagus) (25%) Sight, Smell, Taste, Thought of food stimulates pancreatic secretion Gastric (Vagus) (10%) Presence of food in stomach by mechanical distention : Gastro Pancreatic reflex

Intestinal. (65%) Secretin & CCK-PZ. Gastrin & VIP Presence of food, HCl in the small intestine. Mechanical distention & chemical components.

Function: � Digestive role: � Neutralization of acids � Lubrication.

Applied aspect Steatorrhoea: Increased lipid in the stool. Cystic fibrosis in pancreas. Decrease exocrine secretion/genetic Pancreatic cholera: Diarrhoea due to Increase VIP secretion