Pain Management in Acute Myocardial Infarction AMI PICO

Pain Management in Acute Myocardial Infarction (AMI)

PICO Question In adults with Opium addiction, presenting with Acute Myocardial Infarction (AMI), what is the benefit of pain management with alternatives analgesics compared To morphine?

• P PICO Question roblem or population : Opium addict Adult Patients that suffer from Acute Myocardial Infarction Pain • I • C ntervention: Use alternatives analgesics are available Except Morphine for AMI patients. omparison: comprehensive evaluation of the rationality of administration of morphine in AMI, and other available analgesics. • O utcome: according side effects and drug-drug interactions of morphine, alternatives analgesics have less interactions with the present patient condition.

• Since the turn of the twentieth century, morphine, an opioid analgesic, has played an integral role in the management of pain in myocardial infarction (MI). • This is attributed to morphine’s effect on reducing blood pressure, slowing heart rate, and relieving anxiety, which may decrease myocardial oxygen demand, added to the fact that morphine has been studied extensively in pain management in many settings.

• However, observational data suggest that morphine administration during acute myocardial infarction (AMI) may have negative consequences. a recent evidence uncovered that morphine may impede gastrointestinal absorption of oral antiplatelet drugs important in reducing mortality in AMI. • We discuss the rationality of morphine use according to recent evidence and the side effects and drug-drug interactions of morphine affecting MI patient Compared with the present alternatives based on the findings of experimental, observational and randomized clinical studies.