Overview of the Harvard Catalyst Imaging program Ron

Overview of the Harvard Catalyst Imaging program Ron Kikinis, MD; Clare Tempany, MD; Valerie Humblet, Ph. D http: //catalyst. harvard. edu July 20, 2009

Harvard Catalyst: The History and the Basics • GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued – BWH/MGH imaging cores • CTSA 2007(Roadmap initiative) • HU- Response-Harvard Catalyst – (PI Lee Nadler/Co-Director: Steve Freedman) – GCRC at BWH incorporated in Center for Clinical Investigation • We are a pan-Harvard enterprise dedicated to improving human health by: – Creating Connections – Enabling research At the Cutting Edge of discovery – Nurturing clinical and translational researchers 1

National Effort in C/T Research 39 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J. Hopkins Duke Emory U. Wash. U. Source: http: //www. ctsaweb. org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium • 30 Imaging programs-(Dan Sullivan/RSNA) 2

Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • Mc. Lean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Red –Imaging Consortium Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 3

Harvard Catalyst • Programs (Selected list) – – – – – Development of Novel C/T Methodologies Biomedical Informatics Research Education, Career Development Pilot studies Community Engagement Design and Biostatistics Diversity and Health Disparities Research Ethics Linkages across the institutions Regulatory Knowledge and Support 4

Harvard Catalyst • Programs – Translational Technologies and Resources • Imaging and Genetics – increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies. 5

Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Consultant William Hanlon, Consultant Robert Lenkinski, Consultant Neil Rofsky, Consultant Clare Tempany, Consultant Ron Kikinis, Consultant Charles Guttmann, Consultant Todd Perlstein, Consultant Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Consultant Simon Warfield, Consultant Annick D. Van den Abbeele, Consultant Jeff Yap, Consultant, Director of Education Valerie Humblet, Imaging Liaison Yong Gao, Imaging Informatics Architect 6

Mission of the Imaging Consortium • Expand imaging in clinical research – Build & deploy infrastructure (expertise in single and cross site image acquisition, image analysis, visualization & data management software tools) – Provide expert consultation in the use of imaging as part of clinical translational research – Educate and advise about available imaging and image processing capabilities in the Harvard environment. – Provide leadership & education at the local and national level 7

Harvard Catalyst website http: //catalyst. harvard. edu/home. html 8

Image Consortium Consultation Service 9

Image Consortium Consultation Service 10

Technologies and Expertise • Cancer imaging, MRI, PET, CT, f. MRI, US, pediatric imaging, neuroimaging. • Focused on assisting with planning and design of research proposals and/or methods for image analysis. • Consultation is available for the preparation of a grant or IRB submission. • We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 11

Examples of Imaging Consultation • Standardization of physiologic monitoring system for MRI. – Deployed at 6 institutions (MGH, BWH, BIDMC, CHB, MIT, Harvard) – Creation of a biomedical engineer working group 12

Examples of Imaging Consultation • Development of lingual nerve imaging (MGHBIDMC) – MGH maxillofacial surgeon contacted us regarding pre-op imaging of lingual nerve – Bob Lenkinski (BIDMC) had expertise in MRI nerve imaging – Healthy volunteer was scanned at BIDMC – Head and neck radiologist (BIDMC) will help with reading of images 13

Examples of Imaging Consultation • Study of brain-development in premature infants (CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation in Infants (MGH) 14

CTSC Imaging Informatics Mission • Provide imaging informatics services and support to Harvard Catalyst affiliated – Individual investigators – Organizations (departments, centers, hospitals) • Enable medical imaging data sharing across individual investigators and organizations with dedicated hardware and software • Integrate Imaging Data Management capabilities into i 2 b 2 15

CTSC Imaging Informatics • IT Catalyst infrastructure: – i 2 b 2: scalable computational framework to help translation of genomic findings. – BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. – NA-MIC: robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 16

CTSC Imaging Informatics Dr X Desktop Pediatric rare disease PACS Dr Z Desktop Chronic pain management Dr Y Desktop Alzheimer XNAT Enterprise Annotating Genomic Data #2 Project Management Natural Language Processing Identity Management Data Repository (CRC) Annotating Genomic Data #1 PACS De Identification Of data File Repository Ontology Management Dr W Desktop Quantitative cancer biomarkers Workflow Framework Correlation Analysis i 2 b 2 HIVE 17

CTSC Imaging Informatics Secondary Use of Clinical Imaging Data (Integration with i 2 b 2) Automated MRI measures identify individuals with mild cognitive impairments and Alzheimer’s disease Desikan et al, Brain (published online on May 21, 2009) Standard T 1 MRI scan AUC 0. 95 (specificity 91%, sensitivity 90% to discriminate) MCI from age matched controls 18

Catalyst Educational Program • Creation of a new Harvard post-graduate education program in C/T science (Elliott Antman, BWH) – Introduction to Clinical Investigator Training First course: Nov 2 -6, 2009 – Advanced Clinical Research Training To prepare investigators for writing and conducting a clinical trial – Masters K 12 Programs Preparation for career in clinical research 19

Imaging Consortium Educational Program • Mission: Provide lectures, tutorials, and educational materials promoting the use of imaging to junior investigators and associated research staff • Tailored lectures: Host on-site and based on discipline (oncology, neuro, cardiology, pediatrics, etc) • Generic imaging modules: Basic principles of imaging, quantitative methods, clinical trial design with imaging endpoints, imaging risks and considerations for informed consent forms • Dissemination: through national networks (CTSA, RSNA, IRAT, SNM) 20

Pilot grants • To foster cross-institutional and crossdisciplinary collaboration, Harvard Catalyst offers seed funds in the form of Pilot Grants. – All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. – First round: 62 projects funded (out of 602) – This year (application closed): Pilot Grants will be awarded in the amount of $50, 000, with an award period of one year. (80 grants expected) – Contact: Harvard Catalyst Research Navigators 617 432 -7800 21

http: //catalyst. harvard. edu Image_Consult@catalyst. harvard. edu www. na-mic. org/Wiki/index. php/Collaboration: Harvard_CTSC 22