Overview of the Harvard Catalyst Imaging program Randy

Overview of the Harvard Catalyst Imaging program Randy Gollub, MD, Ph. D; Ron Kikinis, MD; Bruce Rosen, MD, Ph. D; Clare Tempany, MD; Valerie Humblet, Ph. D http: //catalyst. harvard. edu April 14, 2009

Harvard Catalyst: The History and the Basics • GCRC program (20+ yr NCRR/NIH funded clinical trials program) discontinued – BWH/MGH imaging cores • CTSA 2007(Roadmap initiative) • HU- Response-Harvard Catalyst – (PI Lee Nadler/Co-Director: Steve Freedman) – GCRC at BWH incorporated in Center for Clinical Investigation • We are a pan-Harvard enterprise dedicated to improving human health by: – Creating Connections – Enabling research At the Cutting Edge of discovery – Nurturing clinical and translational researchers 1

National Effort in C/T Research 38 AHC/23 states Mayo Clinic Northwestern UC Davis Cornell J. Hopkins Duke Emory U. Wash. U. Source: http: //www. ctsaweb. org/ • Member of the NCRR Clinical and Translational Science Award (CTSA) Consortium-14 new in 08 • Imaging programs-(Dan Sullivan/RSNA) 2

Institutions participating in Harvard CTSC Yearly budget: $38 million (23 NIH + 15 matching) Academic Healthcare Centers • Beth Israel-Deaconess Medical Center • Brigham and Women’s Hospital • Massachusetts General Hospital • Children’s Hospital Boston Specialty Hospitals and Institutes • Dana-Farber Cancer Institute • Forsyth Dental Institute • Joslin Diabetes Center • Massachusetts Eye and Ear Infirmary • Mc. Lean Hospital • Schepens Eye Research Institute Massachusetts Institutes of Technology Red –Imaging Consortium Harvard University • Faculty of Arts and Sciences • Harvard Business School • Harvard School of Dental Medicine • Harvard Divinity School • Graduate School of Design • Graduate School of Education • Kennedy School of Government • Harvard Law School • Harvard Medical School • Harvard School of Public Health • Harvard School of Engineering Community Healthcare Institutions • Cambridge Health Alliance • HMS Department of Ambulatory Care and Prevention at Harvard Pilgrim Healthcare 3

Harvard Catalyst • Programs (Selected list) – – – – – Development of Novel C/T Methodologies Biomedical Informatics Research Education, Career Development Pilot studies Community Engagement Design and Biostatistics Diversity and Health Disparities Research Ethics Linkages across the institutions Regulatory Knowledge and Support 4

Harvard Catalyst • Programs – Translational Technologies and Resources • Imaging and Genetics – increases investigator awareness and utilization of established translational technologies, educates the research community in the underlying principles and application of relevant translational technologies and fosters collaborations to improve these technologies. 5

Imaging Consortium Team Bruce Rosen, Director Randy Gollub, Co-Director Gordon J. Harris, Site Co-Director Robert Lenkinski, Site Co-Director Neil Rofsky, Site Co-Director Clare Tempany, Site Co-Director Ron Kikinis, Site Co-Director Gordon Williams, PI for CTSC Translational Technologies Stephan Voss, Site Co-Director Simon Warfield, Site Co-Director Annick D. Van den Abbeele, Site Co-Director Jeff Yap, Site Co-Director Gordon J. Harris, Site Co-Director Annick D. Van den Abbeele, Site Co-Director William Hanlon, Core Manager Valerie Humblet, Imaging Liaison Yong Gao, XNAT Engineer 6

Mission of the Imaging Consortium • Expand imaging in clinical research – Build infrastructure (software, image analysis and visualization tools, cross-site acquisition tools) – Provide expert consultation in the use of imaging as part of clinical translational research – Educate and advise about available imaging and image processing capabilities in the Harvard environment. – Provide education at the local and national level (participation in RSNA education program) 7

Harvard Catalyst website http: //catalyst. harvard. edu/home. html 8

Harvard Catalyst website

Image Consortium Consultation Service 10

Image Consortium Consultation Service 11

Technologies and Expertise • Cancer imaging, MRI, PET, CT, f. MRI, US, pediatric imaging, neuroimaging. • Focused on assisting with planning and design of research proposals and/or methods for image analysis. • Consultation is available for the preparation of a grant or IRB submission. • We do not (yet) provide ongoing support for the implementation of new studies or the analysis of data from existing studies. 12

Examples of Imaging Consultation • Standardization of physiologic monitoring system for MRI. • Development of lingual nerve imaging (MGHBIDMC) • Multi-site structural and functional neuroimaging (BIDMC-MGH) 13

Examples of Imaging Consultation • Study of brain-development in premature infants (CHB-BWH-MGH) CHB: new Fetal-Neonatal Neuroimaging and Developmental Science Center Slicer (BWH): quantitative tractography (Gilmore, 2007 AJNR) Optical Imaging of Cerebral Oxygenation in Infants (MGH) 14

Medical Imaging Informatics • Examples: – Clinical: • Ruling out appendicitis based on CT scans. Are there metrics that can be found by analyzing clinical data? • Quantitative output from Freesurfer for Alzheimer disease – Research: • Helping TIMC get easier access to PACS system for clinical trials 15

Medical Imaging Informatics • IT Catalyst infrastructure: – i 2 b 2: scalable computational framework to help translation of genomic findings. – BIRN: XNAT imaging informatics platform: large collections of images and study-specific metadata to be managed by image-driven clinical translational research groups. – NA-MIC: robust, open source solutions for medical image analysis, visualization and management software tools by the creation of a “desktop” version of XNAT. Key image analysis software tools: Slicer, Freesurfer. 16

Medical Imaging Informatics Dr X Desktop Pediatric rare disease PACS Dr Z Desktop Chronic pain management Dr Y Desktop Alzheimer XNAT Enterprise Annotating Genomic Data #2 Project Management Natural Language Processing Identity Management Data Repository (CRC) Annotating Genomic Data #1 PACS De Identification Of data File Repository Ontology Management Dr W Desktop Quantitative cancer biomarkers Workflow Framework Correlation Analysis i 2 b 2 HIVE 17

Educational Opportunities proposal • Nanocourse: – Imaging 101 to increase knowledge about imaging • More advanced classes for radiologists: – – – Tumor metrics Radiation safety issues for IRB submission Hands-on classes on data analysis Imaging perfusion Example: www. na-mic. org/Wiki/images/8/8 b/Slicer 3 Training_Change. Tracker. ppt 18

Pilot funds • Eligibility: All Harvard faculty are eligible to apply, regardless of degree or institutional affiliation. • First round: 62 projects funded (out of 602) • Funds: Pilot Grants will be awarded in the amount of $50, 000, with an award period of one year. (80 grants expected) • Deadlines: Letter of intent: May 13, 2009 Full application: June 12, 2009 • Contact: Harvard Catalyst Research Navigators 617 432 -7800 19

http: //catalyst. harvard. edu Image_Consult@catalyst. harvard. edu www. na-mic. org/Wiki/index. php/Collaboration: Harvard_CTSC 20